• Review

    Current and emerging therapies for neuromyelitis optica

    Cong Zhao , Hong-Zeng Li , Ya-Nan Bai , Zhu-Yi Li , Jun Guo
    Neuromyelitis optica (NMO) is an autoimmune demyelinating disease that mainly affects the optic nerve and spinal cord, potentially resulting in blindness and paralysis. Once thought to be a clinical variant of multiple sclerosis, NMO is currently considered as a different disease with its own features due to the identification of a specific autoantibody against aquaporin 4. Given the high risk of disability, treatment should be launched once the diagnosis is established. Evidence from clinical practice showed that traditional immunosuppressive agents affecting the function of T and B cells...
    Published on: 20 Jun 2016
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  • Review

    Statins in acute neurologic disease: which one, which dose, when to start, and when not to stop

    Bong-Su Kang , Gene Sung , May Kim-Tenser , Nerses Sanossian
    Statins could have physiologic properties that may benefit patients that have been diagnosed with various acute neurological diseases. This review aims tosummarize the literature pertaining to stain use in acute neurological disease such as subarachnoid hemorrhage, intracerebral hemorrhage (ICH), cerebral ischemia (CI), traumatic brain injury, status epilepticus and meningitis. The authors reviewed published abstracts and manuscripts pertaining to experimental and clinical trials relevant to statins in acute neurological disease. Although acute statin therapy in the setting of subarachnoid...
    Published on: 20 Jun 2016
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  • Case Report

    Huge supratentorial cortical ependymoma in a young child: case report and literature review

    Mehdi Darmoul , Mohamed Kilani , Atef Ben Nsir , Mohamed Nejib Hattab
    Supratentorial cortical ependymomas are uncommon in the pediatric population and extremely rare in very young children. Histologically, tumors of the anaplastic type are also less common in children. The authors report one case of anaplastic cortical ependymoma in a 16-month-old girl who presented with a 7-day history of left side weakness and rapid neurological deterioration. Brain imaging with computed tomography and magnetic resonance imaging scanning showed a huge right fronto-parietal cystic and solid lesion compressing the brain parenchyma. The young child was operated via a...
    Published on: 20 Jun 2016
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  • Commentary

    Meningeal inflammation and multiple sclerosis

    Li-Ping Liu
    Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Inflammation in MS is characterized by infiltration of peripheral immune cells into the CNS, especially in the meninges. The infiltration into meninges, which has been referred to as tertiary lymphoid tissues (TLTs), is a likely first step preceding infiltration into the CNS parenchyma. These invading autoreactive immune cells destroy myelin, the insulation surrounding neuronal axons, and cause demyelination in subpial and cortical areas, promoting disease pathogenesis. Experimental...
    Published on: 20 Jun 2016
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