Articles
  • Editorial

    Serum immuno-biomarkers in gliomas

    Robin A. Buerki , Rimas V. Lukas
    Published on: 26 Sep 2016
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  • Editorial

    Interleukin-1beta: a common thread between inflammation, pain and opioid tolerance

    Shekher Mohan
    Published on: 26 Sep 2016
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  • Editorial

    Emerging roles of microglia cells in the regulation of adult neural stem cells

    Eduardo Lira-Diaz , Oscar Gonzalez-Perez
    Published on: 26 Sep 2016
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  • Review

    Immune-to-brain signaling and substrates of altered behavior during inflammation

    Jan Pieter Konsman
    During the systemic inflammatory response to acute infection, and when in a safe environment, endothermic mammals typically display reduced activity and food intake, increased sleep, and the adoption of a curled-up position. These changes in behavior, in concert with fever, are adaptive in that they contribute to host survival. The present review addresses the immune-to-brain signaling pathways as well as possible neural substrates mediating reduced exploration and food intake during acute systemic inflammation. These involve rapid activation of peripheral nerves and glutamatergic brainstem...
    Published on: 26 Sep 2016
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  • Case Report

    A case report of acute pediatric bacterial meningitis due to the rare isolate, Pseudomonas putida

    Grishma V. Kulkarni
    Acute bacterial meningitis (ABM) is the medical emergency which warrants an early diagnosis and an aggressive therapy. Despite the availability of the potent newer antibiotics, the mortality caused by ABM and its complications remain high in India, ranging from 16% to 32%. The aim of this case report is to present the rare isolation of Pseudomonas putida from cerebrospinal fluid sample. Besides this, the author also emphasizes the importance of correctly identifying the organism and thus the selection of the most accurate antibiotic from the susceptibility profile to allow for early...
    Published on: 26 Sep 2016
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  • Case Report

    The expanding spectrum of pediatric anti-glutamic acid decarboxylase antibody mediated CNS disease - a chance association?

    Deepak Menon , Ramshekhar N. Menon , Hardeep Kumar , Ashalatha Radhakrishnan , Sudheeran Kannoth , Muralidharan Nair Nair , Sanjeev Thomas
    Central nervous system autoimmunity in the pediatric age group represents an evolving constellation of various syndromes distinct from the adult age group. One of the rarely described pathogenic auto-antibodies (ab) is the one directed against glutamic acid decarboxylase (GAD). While its pathogenic role is controversial, literature concerning adult patients abounds with heterogeneous presentations with epilepsy often as part of limbic encephalitis or chronic temporal lobe epilepsy and cerebellar ataxia accompanying endocrinopathies or paraneoplastic disorders. Diagnosis is often delayed...
    Published on: 28 Sep 2016
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