• Editorial

    Schizophrenia and comorbid sleep disorders

    Maurits van den Noort , Heike Staudte , Benoît Perriard , Sujung Yeo , Sabina Lim , Peggy Bosch
    Published on: 28 Oct 2016
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  • Review

    Neurological manifestations in Fabry disease

    Joseph Bruno Bidin Brooks , Yara Dadalti Fragoso
    Fabry disease (FD) is a rare, progressive, multisystem and highly debilitating disease. FD is an X-linked lysosome storage disorder that results in α-galactosidase A deficiency. The subsequent accumulation of glycosphingolipids is more evident in vascular endothelium and smooth-muscle cells. The resulting effect of the deposition is generalized inflammation and vasculopathy, which can also affect the central and peripheral nervous system. FD progresses with kidney dysfunction, angiokeratoma of the skin, cardiomyopathy, cerebrovascular events and neurological disorders. In the present...
    Published on: 28 Oct 2016
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  • Original Article

    Possible role of microparticles in neuroimmune signaling of microglial cells

    Stephanie M. Schindler , Ekta Bajwa , Jonathan P. Little , Andis Klegeris
    Aim: Submicron fragments termed microparticles (MPs), derived from all major central nervous system cell types including neurons and glia (microglia, astrocytes, oligodendrocytes), have emerged as novel intercellular signaling agents. This study tested the hypothesis that MPs derived from activated microglia, which represent the mononuclear phagocyte system in the brain, could induce pro-inflammatory and cytotoxic responses of microglia in an autocrine or paracrine manner. Methods: Human THP-1 monocytic cells were used to model human microglia. MPs derived from these cells were reapplied to...
    Published on: 28 Oct 2016
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  • Case Report

    Cerebral venous thrombosis in patient of relapse of ulcerative colitis: report of a case

    Rajat Agarwal , Anuradha Batra , Ish Anand , Davinder Singh Rana , Samir Patel
    Amongst the various systemic complications of ulcerative colitis, cerebral venous thrombosis (CVT) is an uncommon and serious neurological complication mainly associated during episodes of relapse of ulcerative colitis. CVT is suspected to be a consequence of hypercoagulable state occurring during the disease in genetic predisposed persons. Most patients present with rapid neurological deterioration. This devastating intracranial complication requires immediate medical intervention to avoid potentially life threatening consequences. The outcome is good, provided the disease is diagnosed on...
    Published on: 28 Oct 2016
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  • Commentary

    Comments on “Loss of intranetwork and internetwork resting state functional connections with Alzheimer’s disease progression”

    Jiu Chen
    Published on: 28 Oct 2016
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