Editor's Picks
  • Review

    Neuro-oncogenesis and the adult human sub-ventricular zone in high grade glioma

    Sara G. M. Piccirillo
    The review focuses on the role of the sub-ventricular zone, the most well characterized germinal region of adult brain, in the commonest and most aggressive brain tumor in adults, i.e. high grade glioma (HGG). Recent findings from animal models and samples isolated from HGG patients are reviewed here with a focus on the cancer stem cell hypothesis and evolutionary trajectories of tumor growth in patients. The implications of these studies on the development of novel therapeutic approaches aimed at improving HGG patient survival and the need...
    Published on: 15 Feb 2016
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  • Guidelines

    China guidelines for the diagnosis and treatment of myasthenia gravis

    Zhu-Yi Li
    Myasthenia gravis (MG) is a typical autoimmune disease mediated by auto-antibodies, immune cells and complement systems at the postsynaptic membrane of the neuromuscular junction. Over 80 % of MG patients have anti-acetylcholine receptor antibody. This guideline will describe the clinical manifestations and classification, laboratory examinations, diagnosis and differential diagnosis, treatment and prognosis.
    Published on: 20 Jan 2016
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  • Review

    Chronic inflammation drives glioma growth: cellular and molecular factors responsible for an immunosuppressive microenvironment

    Edward T Ha , Joseph P Antonios , Horacio Soto , Robert M Prins , Isaac Yang , Noriyuki Kasahara , Linda M Liau , Carol A Kruse
    This review examines glioma disease initiation, promotion, and progression with a focus on the cell types present within the tumor mass and the molecules responsible for the immunosuppressive microenvironment that are present at each step of the disease. The cell types and molecules present also correlate with the grade of malignancy. An overall "type 2" chronic inflammatory microenvironment develops that facilitates glioma promotion and contributes to the neo-vascularization characteristic of gliomas. An immunosuppressive microenvironment...
    Published on: 28 Aug 2014
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  • Editorial

    The M1/M2 immune polarization concept in microglia: a fair transfer?

    Michel Mittelbronn
    Published on: 27 Jun 2014
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