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  • Technical Note|Open Access

    Classification of brain tumor using devernay sub-pixel edge detection and k-nearest neighbours methodology

    Ayush Arora , Ritesh Kumar , Shubham Tiwari , Mysore Shwetha , Selvam Venkatesan , Ramesh Babu
    Any disease can be treated only once it is imaged, detected and classified. This paper proposes a set of algorithms for classification of a brain tumor with better accuracy and efficiency. The proposal uses a JPEG format of the DICOM image fed into three stages namely pre-processing, segmentation using sub-pixel edge detection method and using the nearest neighbor methodology for the detection and differentiation of benign and malignant tumors. Read more
    This article belongs to the Special Issue Immunotherapeutic Approaches for Treatment of Brain Tumors
    Neuroimmunol Neuroinflammation 2018;5:26. | doi:10.20517/2347-8659.2018.11
    Published on: 19 Jun 2018  | Viewed:106  | Downloaded:5
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  • Review|Open Access

    A concise review of immunotherapy for glioblastoma

    Omer Sager , Ferrat Dincoglan , Selcuk Demiral , Bora Uysal , Hakan Gamsiz , Bahar Dirican , Murat Beyzadeoglu
    Glioblastoma (GB) is the most common and aggressive form of primary brain tumors in adults with a universally poor prognosis despite multimodal management including surgery, chemotherapy and radiation therapy. Among the novel therapeutic strategies, immunotherapy deserves particular attention with its potential to evoke biologic response and harness the host immune system. Considerable success achieved for other tumors has elicited great enthusiasm and prompted research on immunotherapy for GB. While the central nervous system has traditionally been thought of as an immune-privileged site,... Read more
    This article belongs to the Special Issue Immunotherapeutic Approaches for Treatment of Brain Tumors
    Neuroimmunol Neuroinflammation 2018;5:25. | doi:10.20517/2347-8659.2018.12
    Published on: 15 Jun 2018  | Viewed:67  | Downloaded:8
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  • Commentary|Open Access

    Commentary on “Depression severity and its predictors among multiple sclerosis patients in Saudi Arabia: a cross-sectional study”

    Thomas Müller
    Neuroimmunol Neuroinflammation 2018;5:23. | doi:10.20517/2347-8659.2018.27
    Published on: 7 Jun 2018  | Viewed:125  | Downloaded:7
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  • Original Article|Open Access

    Shifting paradigm in brain abscess management at tertiary care centre in Nepal

    Prakash Kafle , Mohan Raj Sharma , Sushil Krishna Shilpakar , Gopal Sedain , Amit Pradhanang , Ram Kumar Shrestha , Binod Raj Bhandari , Christine Groves
    Aim: Brain abscess is a challenging clinical entity with substantial high case fatality rates despite significant advances in imaging techniques, laboratory modalities, surgical interventions, and antimicrobial treatment.Otogenic and cardiogenic sources are among the most common. Classic clinical presentation is seen in very few cases only. Burr hole with aspiration works well with good clinical outcomes. Control of primary source in cases of ear infection in the single setting results in good outcomes, reduces for additional surgery, and decreases the duration of hospital stay. Methods:... Read more
    Neuroimmunol Neuroinflammation 2018;5:24. | doi:10.20517/2347-8659.2018.10
    Published on: 7 Jun 2018  | Viewed:91  | Downloaded:11
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  • Commentary|Open Access

    Commentary on interactions between neurotropic pathogens, neuroinflammatory pathways, and autophagic neural cell death

    Michaela Cellina , Marcello Orsi
    Neuroimmunol Neuroinflammation 2018;5:22. | doi:10.20517/2347-8659.2018.15
    Published on: 5 Jun 2018  | Viewed:90  | Downloaded:7
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  • Original Article|Open Access

    Surgical management of clinoidal meningiomas: 10 cases analysis

    Shamsul Alam , Bipin Kumar Chaurasia , Narendra Shalike , Abu Naim Wakil Uddin , Dhiman Chowdhury , Akhlaque Hossain Khan , Ayub Ansari , Kanak Kanti Barua , Mashiur Rahman Majumder
    Aim: The purpose of this article is to advocate standard skull base technique for removing the clinoidal meningioma and to delineate the technique’s advantages that aid in achieving an improved extent of tumor resection and enhancing the patients’ overall outcome, specially their visual outcome. Methods: A retrospective analysis was performed on 10 consecutive patients with clinoidal meningiomas who underwent surgical resection at the Bangabandhu Sheikh Mujib Medical University and other private clinics between May 2013 and July 2016. A standard pterional craniotomy technique consisting of... Read more
    This article belongs to the Special Issue Brain Tumor
    Neuroimmunol Neuroinflammation 2018;5:21. | doi:10.20517/2347-8659.2017.64
    Published on: 24 May 2018  | Viewed:411  | Downloaded:18
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  • Case Report|Open Access

    Hypoparathyroidism presenting with late onset seizures - a report of two cases from rural India

    Archana Verma , Alok Kumar
    Hypoparathyroidism leading to hypocalcaemia is an important treatable cause of recurrent seizures. Neurological manifestations due to hypoparathyroidism include: seizures, paresthesia, depression, psychosis, extra pyramidal symptoms, and features of raised intracranial pressure. Seizures may be the presenting symptoms preceding other signs of hypocalcaemia. Primary hypoparathyroidism presenting for the first time as seizures in the elderly is quite rare. Here we report two cases of hypoparathyroidism presenting with seizures in the elderly as the sole manifestation of hypocalcaemia. The... Read more
    Neuroimmunol Neuroinflammation 2018;5:20. | doi:10.20517/2347-8659.2017.65
    Published on: 23 May 2018  | Viewed:152  | Downloaded:8
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  • Editorial|Open Access

    Bone mineral density in patients with multiple sclerosis

    Chrissa Sioka , Andreas Fotopoulos
    Neuroimmunol Neuroinflammation 2018;5:18. | doi:10.20517/2347-8659.2018.06
    Published on: 22 May 2018  | Viewed:87  | Downloaded:12
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  • Case Report|Open Access

    Demyelinating central nervous system lesions, following the use of tumor necrosis factor alpha antagonist

    Emmanuel Bogdos , Sofia Markoula , Anastasia Zikou , Paraskevi Voulgari , Aleksandros Drosos , Spyridon Konitsiotis
    Tumor necrosis factor alpha (TNFα) antagonists have been a valuable tool in treating patients with rheumatoid arthritis (RA), but reports and case series of neurological adverse events due to TNFα antagonists have been reported. Furthermore, central nervous system (CNS) lymphoma always remains a remote, yet a worrisome complication in RA patients, especially in those under treatment with methotrexate (MTX). We present a female patient with RA with tumor-like active demyelinating lesions attributed to TNFα antagonist, confirmed by an FNA biopsy, otherwise clinically and radiologically... Read more
    Neuroimmunol Neuroinflammation 2018;5:19. | doi:10.20517/2347-8659.2018.07
    Published on: 22 May 2018  | Viewed:122  | Downloaded:6
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  • Commentary|Open Access

    The emerging TDP-43 proteinopathy

    George P. Paraskevas , Mara Bourbouli , Ioannis Zaganas , Elisabeth Kapaki
    Neuroimmunol Neuroinflammation 2018;5:17. | doi:10.20517/2347-8659.2018.18
    Published on: 10 May 2018  | Viewed:518  | Downloaded:32
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  • Commentary|Open Access

    Customized autophagy: a long way to go

    Jayantee Kalita , Usha Kant Misra , Alok Kumar
    Neuroimmunol Neuroinflammation 2018;5:16. | doi:10.20517/2347-8659.2018.22
    Published on: 7 May 2018  | Viewed:372  | Downloaded:27
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  • Commentary|Open Access

    Sleep disturbance and treatment adherence: commentary on the study by Bosch et al. (2016)

    Kanako Ishizuka , Toshiya Inada
    Neuroimmunol Neuroinflammation 2018;5:15. | doi:10.20517/2347-8659.2018.14
    Published on: 26 Apr 2018  | Viewed:184  | Downloaded:29
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  • Original Article|Open Access

    Precentral gyrus abnormal connectivity in male and female patients with schizophrenia

    Mahdi Zarei
    Aim: Dysfunction of the precentral gyrus plays a role in the impairments of voluntary movement associated with schizophrenia and it has significantly reduced functional activity in patients with schizophrenia. The aim of this study was to demonstrate the precentral gyrus alteration and its abnormal connectivity in schizophrenia. Methods: The region of interest-based analysis method was used to investigate the precentral gyrus connectivity alteration in schizophrenia. The resting-state functional magnetic resonance imaging data of healthy control subjects and patients with schizophrenia... Read more
    Neuroimmunol Neuroinflammation 2018;5:13. | doi:10.20517/2347-8659.2018.02
    Published on: 23 Apr 2018  | Viewed:773  | Downloaded:30
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  • Case Report|Open Access

    Very rare upperdorsal intramedullary epidermoid with paraplegia: a case report

    Md. Atikur Rahman , Bipin Kumar Chaurasia , Md. Arif Hossain , Saequa Habib , Kanak Kanti Barua
    Intramedullary upperdorsal epidermoid tumor is very rare. As far as we know, a small number of epidermoid tumors in the spinal cord have been reported in the journal for a long time. Most of the time, the spinal cord epidermoids are intradural extramedullary. We are reporting a case of a 21-year-old young man with paraplegia and upper dorsal pain for 6 months with normal physical findings. Magnetic resonance imaging scan shows that spinal intramedullary space occupying lesions in the dorsal 2/3 (D2/3) level. Total clearance was accomplished by performing laminectomy. Day to day paraplegia... Read more
    Neuroimmunol Neuroinflammation 2018;5:14. | doi:10.20517/2347-8659.2017.57
    Published on: 23 Apr 2018  | Viewed:495  | Downloaded:19
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  • Commentary|Open Access

    Multiple sclerosis: depression and disability are globally shared issues of concern

    Victor M. Rivera
    Neuroimmunol Neuroinflammation 2018;5:12. | doi:10.20517/2347-8659.2018.16
    Published on: 18 Apr 2018  | Viewed:707  | Downloaded:23
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  • Original Article|Open Access

    Acetaminophen metabolites p-aminophenol and AM404 inhibit microglial activation

    Wyatt T. Slattery , Andis Klegeris
    Aim: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline, deposits of amyloid beta and neurofibrillary tangles. Inflammation facilitated by microglia, the resident immune cells of the brain, contribute to the pathogenesis of AD. Epidemiological data indicate that nonsteroidal anti-inflammatory drugs (NSAIDs), which are cyclooxygenase (COX) inhibitors, reduce the risk of developing AD when administered over the course of two or more years. The mechanisms underlying this protective effect are unknown. Acetaminophen (paracetamol), which is not effective... Read more
    Neuroimmunol Neuroinflammation 2018;5:11. | doi:10.20517/2347-8659.2018.05
    Published on: 12 Apr 2018  | Viewed:834  | Downloaded:48
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  • Review|Open Access

    MicroRNA-126 is a prospective target for vascular disease

    Mei-Jie Qu , Jia-Ji Pan , Xiao-Jing Shi , Zhi-Jun Zhang , Yao-Hui Tang , Guo-Yuan Yang
    MicroRNA-126 was involved in angiogenesis during physiological and pathological process. It was mainly expressed in endothelial cells, and defined as a pivotal biological molecule associated with vascular disease. Increased microRNA-126 in endothelial cells promotes angiogenesis in ischemic stroke, repairs impaired endothelial cells in atherosclerosis, and attenuates vascular dysfunction in diabetics. By contrast, microRNA-126 transferred from endothelial cell to smooth muscle cells could lead to proliferation that induced intimal hyperplasia. Additionally, microRNA-126 could be a tumor... Read more
    Neuroimmunol Neuroinflammation 2018;5:10. | doi:10.20517/2347-8659.2018.01
    Published on: 9 Apr 2018  | Viewed:2122  | Downloaded:54
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  • Original Article|Open Access

    Applying clustering coefficient to the pattern of international author collaboration in neuroimmunology and neuroinflammation

    Chen-Fang Hsu , Tsair-Wei Chien , Julie Chi Chow , Willy Chou
    Aim: To apply cluster coefficient (CC) to the pattern of international author collaborations in neuroimmunology and neuroinflammation using data from Medline and to visualize results using Google maps and social network analysis (SNA). Methods: Selecting 2799 abstracts, author names, countries, and keywords on January 22, 2018 from Medline based on keyword neuroimmunology (or neuroinflammation) within the article title since 1982, we reported following features: (1) nation distribution for the 1st author’s nationality; (2) eminent journals and authors in the field of neuroimmunology and... Read more
    Neuroimmunol Neuroinflammation 2018;5:9. | doi:10.20517/2347-8659.2018.03
    Published on: 30 Mar 2018  | Viewed:2576  | Downloaded:54
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  • Original Article|Open Access

    Depression severity and its predictors among multiple sclerosis patients in Saudi Arabia: a cross-sectional study

    Adel Ali Alhazzani , Mohammed Saeed Alqahtani , Hassan Ogran , Osamah Hussain Abuhawi , Abdulrahman Yahya Asiri , Ali Mohammed Al-Hanash , Reem Ali AlQahtany , Adel Ali Alfaifi , Abdullmgeed Abdullah Asiri , Muhannad Ali Asiri
    Aim: To assess depression severity among multiple sclerosis (MS) patients. Methods: Our survey was carried out among a sample of 598 MS patients (35.8% were males and 64.2% were females) from all different regions of KSA. A self-administered questionnaire was used for data collection. The Chi-square test was applied to examine the association between demographic factors, depression severity and level of disability. Results: The mean age of patients at the time of diagnosis was 26.1 ± 7.9 years (range 15 to 60 years). The mean duration of the disease was 6.6 ± 4.8 years. More than quarter of... Read more
    Neuroimmunol Neuroinflammation 2018;5:8. | doi:10.20517/2347-8659.2017.55
    Published on: 23 Mar 2018  | Viewed:2156  | Downloaded:82
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  • Case Report|Open Access

    Steroids and plasma exchange in Isaacs' syndrome with anti-Caspr2 antibodies

    Daniele Orsucci , Gianfranco Cafforio , Gianluca Moscato , Alessandro Napolitano , Marco Margelli , Monica Mazzoni
    Isaacs’ syndrome is a disease characterized by nerve hyperexcitability. The patients are commonly treated with symptomatic therapies and immunomodulatory approaches, but no clinical trials are available to date. Here, we report the case of an anti-Caspr2-positive patient, presenting with continuous muscle twitches and diffuse muscle pain. He experienced a nearly complete clinical response to intravenous high-dose steroids combined with plasma exchange, sustained for at least 1 year. Our experience suggests that methylprednisolone 1000 mg/day × 5 days and consecutive tapering followed by... Read more
    Neuroimmunol Neuroinflammation 2018;5:7. | doi:10.20517/2347-8659.2017.67
    Published on: 8 Mar 2018  | Viewed:4420  | Downloaded:102
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Neuroimmunology and Neuroinflammation ISSN 2349-6142 (Online), ISSN 2347-8659 (Print)
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