Latest
  • Case Report|Open Access

    Cerebral fat embolism syndrome after long bone fracture due to traffic accident: a case report

    Xing-Yong Chen, Jian-Ming Fan, Ming-Feng Deng, Ting Jiang, Feng Luo
    Cerebral fat embolism syndrome (CFES) is an uncommon but serious complication of long bone fracture. We reported a 19-year-old male patient who sustained CFES due to multiple limbs long bone fractures after a traffic accident injury. He gradually developed into coma within 24 h after his injury. The arterial blood gas analyses were normal. There was a small amount of gas in the right pleural cavity on the thoracic computed tomography (CT). Although there were no remarkable intracranial abnormalities on the initial brain CT findings, the typical brain magnetic resonance imaging (MRI)... Read more
    Neuroimmunol Neuroinflammation 2018;5:31. | doi:10.20517/2347-8659.2018.23
    Published on: 1 Aug 2018  | Viewed:82  | Downloaded:10
    +HTML| PDF
  • Review|Open Access

    Therapeutic approach targeting apolipoprotein E binding region and low-density lipoprotein receptor for Alzheimer’s disease

    Michael Leon, Darrell Sawmiller, Brian Giunta, Jun Tan
    Approximately 13% of the population over the age of 65 years is estimated to have AD. The total number of cases is expected to increase over the coming decades. The apolipoprotein E (ApoE) genotype is the greatest genetic determinant for Alzheimer’s disease (AD) development. The ApoE4 allele increases the risk of AD by 4 to 14 fold while the ApoE2 allele has an opposing effect; decreasing risk. Indeed many studies have demonstrated that carriers of the ApoE2 allele are associated with greater likelihood of survival to advanced age, superior verbal learning ability in advanced age, and... Read more
    Neuroimmunol Neuroinflammation 2018;5:30. | doi:10.20517/2347-8659.2018.26
    Published on: 31 Jul 2018  | Viewed:202  | Downloaded:7
    +HTML| PDF
  • Review|Open Access

    Immunotherapy for pediatric brain tumors

    Daniel B. Landi, Eric M. Thompson, David M. Ashley
    Immunotherapy, while effective against lymphoid cancers and some solid tumors, has shown less benefit against pediatric brain tumors. Tumor heterogeneity, a suppressive immune microenvironment, and the blood-brain barrier have the potential to diminish any immune-based approach and limit efficacy. More importantly, most pediatric brain tumors are immunologically quiescent, stemming from a low mutational burden. This review focuses on innate vs. adaptive immunotherapeutic approaches and describes how the immunologic context of pediatric brain tumors can help identify well-suited... Read more
    This article belongs to the Special Issue Immunotherapeutic Approaches for Treatment of Brain Tumors
    Neuroimmunol Neuroinflammation 2018;5:29. | doi:10.20517/2347-8659.2018.35
    Published on: 23 Jul 2018  | Viewed:977  | Downloaded:81
    +HTML| PDF
  • Case Report|Open Access

    Streptococcus gallolyticus meningocephalitis in adults: the first case report in China

    Yue-Man Dai, Min Zhao, Hong-Ji Lu, Li-Xin Wan
    We report on the first case of a Streptococcus gallolyticus meningocephalitis in China. The bacterium was first isolated from the patient’s cerebrospinal fluid and has so far not been associated with human infections of the central nervous system. We hope our case report can give some references for the diagnosis and treatment of the Streptococcus gallolyticus meningocephalitis in China. Read more
    Neuroimmunol Neuroinflammation 2018;5:28. | doi:10.20517//2347-8659.2018.09
    Published on: 16 Jul 2018  | Viewed:562  | Downloaded:4
    +HTML| PDF
  • Review|Open Access

    Photodynamic therapy mediated immune therapy of brain tumors

    Henry Hirschberg, Kristian Berg, Qian Peng
    Photodynamic therapy of tumors requires the topical, systemic or oral administration of a photosensitizing compound,illumination of the tumor area by light of a specific wavelength and the presence of oxygen. Light activation of the photosensitizer transfers energy to molecular oxygen creating singlet oxygen, a highly reactive and toxic species that rapidly reacts with cellular components causing oxidative damage, ultimately leading to cell death. Tumor destruction caused by photodynamic therapy is not only a result of direct tumor cell toxicity via the generation of reactive oxygen species... Read more
    This article belongs to the Special Issue Immunotherapeutic Approaches for Treatment of Brain Tumors
    Neuroimmunol Neuroinflammation 2018;5:27. | doi:10.20517/2347-8659.2018.31
    Published on: 10 Jul 2018  | Viewed:641  | Downloaded:50
    +HTML| PDF
  • Technical Note|Open Access

    Classification of brain tumor using devernay sub-pixel edge detection and k-nearest neighbours methodology

    Ayush Arora, Ritesh Kumar, Shubham Tiwari, Mysore Shwetha, Selvam Venkatesan, Ramesh Babu
    Any disease can be treated only once it is imaged, detected and classified. This paper proposes a set of algorithms for classification of a brain tumor with better accuracy and efficiency. The proposal uses a JPEG format of the DICOM image fed into three stages namely pre-processing, segmentation using sub-pixel edge detection method and using the nearest neighbor methodology for the detection and differentiation of benign and malignant tumors. Read more
    This article belongs to the Special Issue Immunotherapeutic Approaches for Treatment of Brain Tumors
    Neuroimmunol Neuroinflammation 2018;5:26. | doi:10.20517/2347-8659.2018.11
    Published on: 19 Jun 2018  | Viewed:495  | Downloaded:20
    +HTML| PDF
  • Review|Open Access

    A concise review of immunotherapy for glioblastoma

    Omer Sager, Ferrat Dincoglan, Selcuk Demiral, Bora Uysal, Hakan Gamsiz, Bahar Dirican, Murat Beyzadeoglu
    Glioblastoma (GB) is the most common and aggressive form of primary brain tumors in adults with a universally poor prognosis despite multimodal management including surgery, chemotherapy and radiation therapy. Among the novel therapeutic strategies, immunotherapy deserves particular attention with its potential to evoke biologic response and harness the host immune system. Considerable success achieved for other tumors has elicited great enthusiasm and prompted research on immunotherapy for GB. While the central nervous system has traditionally been thought of as an immune-privileged site,... Read more
    This article belongs to the Special Issue Immunotherapeutic Approaches for Treatment of Brain Tumors
    Neuroimmunol Neuroinflammation 2018;5:25. | doi:10.20517/2347-8659.2018.12
    Published on: 15 Jun 2018  | Viewed:493  | Downloaded:58
    +HTML| PDF
  • Commentary|Open Access

    Commentary on “Depression severity and its predictors among multiple sclerosis patients in Saudi Arabia: a cross-sectional study”

    Thomas Müller
    Neuroimmunol Neuroinflammation 2018;5:23. | doi:10.20517/2347-8659.2018.27
    Published on: 7 Jun 2018  | Viewed:309  | Downloaded:15
    +HTML| PDF
  • Original Article|Open Access

    Shifting paradigm in brain abscess management at tertiary care centre in Nepal

    Prakash Kafle, Mohan Raj Sharma, Sushil Krishna Shilpakar, Gopal Sedain, Amit Pradhanang, Ram Kumar Shrestha, Binod Raj Bhandari, Christine Groves
    Aim: Brain abscess is a challenging clinical entity with substantial high case fatality rates despite significant advances in imaging techniques, laboratory modalities, surgical interventions, and antimicrobial treatment.Otogenic and cardiogenic sources are among the most common. Classic clinical presentation is seen in very few cases only. Burr hole with aspiration works well with good clinical outcomes. Control of primary source in cases of ear infection in the single setting results in good outcomes, reduces for additional surgery, and decreases the duration of hospital stay. Methods:... Read more
    This article belongs to the Special Issue Updates on neuro-immunological and neuro-inflammatory lesions
    Neuroimmunol Neuroinflammation 2018;5:24. | doi:10.20517/2347-8659.2018.10
    Published on: 7 Jun 2018  | Viewed:358  | Downloaded:19
    +HTML| PDF
  • Commentary|Open Access

    Commentary on interactions between neurotropic pathogens, neuroinflammatory pathways, and autophagic neural cell death

    Michaela Cellina, Marcello Orsi
    Neuroimmunol Neuroinflammation 2018;5:22. | doi:10.20517/2347-8659.2018.15
    Published on: 5 Jun 2018  | Viewed:273  | Downloaded:15
    +HTML| PDF
  • Original Article|Open Access

    Surgical management of clinoidal meningiomas: 10 cases analysis

    Shamsul Alam, Bipin Kumar Chaurasia, Narendra Shalike, Abu Naim Wakil Uddin, Dhiman Chowdhury, Akhlaque Hossain Khan, Ayub Ansari, Kanak Kanti Barua, Mashiur Rahman Majumder
    Aim: The purpose of this article is to advocate standard skull base technique for removing the clinoidal meningioma and to delineate the technique’s advantages that aid in achieving an improved extent of tumor resection and enhancing the patients’ overall outcome, specially their visual outcome. Methods: A retrospective analysis was performed on 10 consecutive patients with clinoidal meningiomas who underwent surgical resection at the Bangabandhu Sheikh Mujib Medical University and other private clinics between May 2013 and July 2016. A standard pterional craniotomy technique consisting of... Read more
    This article belongs to the Special Issue Brain Tumor
    Neuroimmunol Neuroinflammation 2018;5:21. | doi:10.20517/2347-8659.2017.64
    Published on: 24 May 2018  | Viewed:967  | Downloaded:31
    +HTML| PDF
  • Case Report|Open Access

    Hypoparathyroidism presenting with late onset seizures - a report of two cases from rural India

    Archana Verma, Alok Kumar
    Hypoparathyroidism leading to hypocalcaemia is an important treatable cause of recurrent seizures. Neurological manifestations due to hypoparathyroidism include: seizures, paresthesia, depression, psychosis, extra pyramidal symptoms, and features of raised intracranial pressure. Seizures may be the presenting symptoms preceding other signs of hypocalcaemia. Primary hypoparathyroidism presenting for the first time as seizures in the elderly is quite rare. Here we report two cases of hypoparathyroidism presenting with seizures in the elderly as the sole manifestation of hypocalcaemia. The... Read more
    Neuroimmunol Neuroinflammation 2018;5:20. | doi:10.20517/2347-8659.2017.65
    Published on: 23 May 2018  | Viewed:270  | Downloaded:18
    +HTML| PDF
  • Editorial|Open Access

    Bone mineral density in patients with multiple sclerosis

    Chrissa Sioka, Andreas Fotopoulos
    Neuroimmunol Neuroinflammation 2018;5:18. | doi:10.20517/2347-8659.2018.06
    Published on: 22 May 2018  | Viewed:171  | Downloaded:20
    +HTML| PDF
  • Case Report|Open Access

    Demyelinating central nervous system lesions, following the use of tumor necrosis factor alpha antagonist

    Emmanuel Bogdos, Sofia Markoula, Anastasia Zikou, Paraskevi Voulgari, Aleksandros Drosos, Spyridon Konitsiotis
    Tumor necrosis factor alpha (TNFα) antagonists have been a valuable tool in treating patients with rheumatoid arthritis (RA), but reports and case series of neurological adverse events due to TNFα antagonists have been reported. Furthermore, central nervous system (CNS) lymphoma always remains a remote, yet a worrisome complication in RA patients, especially in those under treatment with methotrexate (MTX). We present a female patient with RA with tumor-like active demyelinating lesions attributed to TNFα antagonist, confirmed by an FNA biopsy, otherwise clinically and radiologically... Read more
    Neuroimmunol Neuroinflammation 2018;5:19. | doi:10.20517/2347-8659.2018.07
    Published on: 22 May 2018  | Viewed:239  | Downloaded:18
    +HTML| PDF
  • Commentary|Open Access

    The emerging TDP-43 proteinopathy

    George P. Paraskevas, Mara Bourbouli, Ioannis Zaganas, Elisabeth Kapaki
    Neuroimmunol Neuroinflammation 2018;5:17. | doi:10.20517/2347-8659.2018.18
    Published on: 10 May 2018  | Viewed:619  | Downloaded:38
    +HTML| PDF
  • Commentary|Open Access

    Customized autophagy: a long way to go

    Jayantee Kalita, Usha Kant Misra, Alok Kumar
    Neuroimmunol Neuroinflammation 2018;5:16. | doi:10.20517/2347-8659.2018.22
    Published on: 7 May 2018  | Viewed:431  | Downloaded:36
    +HTML| PDF
  • Commentary|Open Access

    Sleep disturbance and treatment adherence: commentary on the study by Bosch et al. (2016)

    Kanako Ishizuka, Toshiya Inada
    Neuroimmunol Neuroinflammation 2018;5:15. | doi:10.20517/2347-8659.2018.14
    Published on: 26 Apr 2018  | Viewed:216  | Downloaded:34
    +HTML| PDF
  • Original Article|Open Access

    Precentral gyrus abnormal connectivity in male and female patients with schizophrenia

    Mahdi Zarei
    Aim: Dysfunction of the precentral gyrus plays a role in the impairments of voluntary movement associated with schizophrenia and it has significantly reduced functional activity in patients with schizophrenia. The aim of this study was to demonstrate the precentral gyrus alteration and its abnormal connectivity in schizophrenia. Methods: The region of interest-based analysis method was used to investigate the precentral gyrus connectivity alteration in schizophrenia. The resting-state functional magnetic resonance imaging data of healthy control subjects and patients with schizophrenia... Read more
    Neuroimmunol Neuroinflammation 2018;5:13. | doi:10.20517/2347-8659.2018.02
    Published on: 23 Apr 2018  | Viewed:927  | Downloaded:32
    +HTML| PDF
  • Case Report|Open Access

    Very rare upperdorsal intramedullary epidermoid with paraplegia: a case report

    Md. Atikur Rahman, Bipin Kumar Chaurasia, Md. Arif Hossain, Saequa Habib, Kanak Kanti Barua
    Intramedullary upperdorsal epidermoid tumor is very rare. As far as we know, a small number of epidermoid tumors in the spinal cord have been reported in the journal for a long time. Most of the time, the spinal cord epidermoids are intradural extramedullary. We are reporting a case of a 21-year-old young man with paraplegia and upper dorsal pain for 6 months with normal physical findings. Magnetic resonance imaging scan shows that spinal intramedullary space occupying lesions in the dorsal 2/3 (D2/3) level. Total clearance was accomplished by performing laminectomy. Day to day paraplegia... Read more
    Neuroimmunol Neuroinflammation 2018;5:14. | doi:10.20517/2347-8659.2017.57
    Published on: 23 Apr 2018  | Viewed:563  | Downloaded:24
    +HTML| PDF
  • Commentary|Open Access

    Multiple sclerosis: depression and disability are globally shared issues of concern

    Victor M. Rivera
    Neuroimmunol Neuroinflammation 2018;5:12. | doi:10.20517/2347-8659.2018.16
    Published on: 18 Apr 2018  | Viewed:758  | Downloaded:30
    +HTML| PDF
Neuroimmunology and Neuroinflammation ISSN 2349-6142 (Online), ISSN 2347-8659 (Print)
Partners
Copyright © 2018 OAE Publishing Inc. All Rights Reserved.