Latest
  • Topic: Stroke|Open Access

    Inflammation and genetic factors in stroke pathogenesis

    Hua Su
    Neuroimmunol Neuroinflammation 2017;4:260-2. | doi:10.20517/2347-8659.2017.22
    Published on: 8 Dec 2017  | Viewed:186  | Downloaded:9
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  • Topic: Alzheimer’s Disease|Open Access

    Altered filamin A enables amyloid beta-induced tau hyperphosphorylation and neuroinflammation in Alzheimer’s disease

    Lindsay H. Burns , Hoau-Yan Wang
    Alzheimer’s disease (AD) is a neurodegenerative disease with proteopathy characterized by abnormalities in amyloid beta (Aβ) and tau proteins. Defective amyloid and tau propagate and aggregate, leading to eventual amyloid plaques and neurofibrillary tangles. New data show that a third proteopathy, an altered conformation of the scaffolding protein filamin A (FLNA), is critically linked to the amyloid and tau pathologies in AD. Altered FLNA is pervasive in AD brain and without apparent aggregation. In a striking interdependence, altered FLNA is both induced by Aβ and required for two... Read more
    Neuroimmunol Neuroinflammation 2017;4:263-71. | doi:10.20517/2347-8659.2017.50
    Published on: 8 Dec 2017  | Viewed:526  | Downloaded:14
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  • Letter to Editor|Open Access

    Transcranial magnetic stimulation for schizophrenia: potential and risks

    Peggy Bosch , Sujung Yeo , Heike Staudte , Pia Barisch , Sabina Lim , Maurits van den Noort
    Neuroimmunol Neuroinflammation 2017;4:258-9. | doi:10.20517/2347-8659.2017.48
    Published on: 6 Dec 2017  | Viewed:57  | Downloaded:10
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  • Editorial|Open Access

    Neuron specific enolase is a potential target for regulating neuronal cell survival and death: implications in neurodegeneration and regeneration

    Rachel Polcyn , Mollie Capone , Azim Hossain , Denise Matzelle , Naren L. Banik , Azizul Haque
    Neuroimmunol Neuroinflammation 2017;4:254-7. | doi:10.20517/2347-8659.2017.59
    Published on: 6 Dec 2017  | Viewed:43  | Downloaded:10
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  • Original Article|Open Access

    Neuroprotection by minocycline in murine traumatic spinal cord injury: analyses of matrix metalloproteinases

    Tiffany Rice , Jennifer E.A. Larsen , Hui Li , Robert K. Nuttall , Peter H. Larsen , Steven Casha , John Hurlbert , Dylan R. Edwards , V. Wee Yong
    Aim: Minocycline has neuroprotective activities in several models of neurological disorders including spinal cord injury (SCI) where it prevents axonal loss and improves functional recovery. There are still gaps of knowledge on minocycline in SCI including whether it ameliorates neuronal loss at the focal site of trauma, and whether minocycline reduces the activity of matrix metalloproteinases (MMPs), a family of enzymes implicated in the pathophysiology of SCI. This study addressed these gaps. Methods: Mice were treated with either minocycline or vehicle control after a spinal cord... Read more
    Neuroimmunol Neuroinflammation 2017;4:243-53. | doi:10.20517/2347-8659.2017.51
    Published on: 28 Nov 2017  | Viewed:2079  | Downloaded:24
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  • Case Report|Open Access

    Sparganosis of the brain: a case report and brief review

    Hai-Xia Li , Shi-Hai Luan , Wei Guo , Ling-Yang Hua , Hong-Da Zhu , Jiao-Jiao Deng , Hai-Liang Tang , Xian-Cheng Chen , Qing Xie , Ye Gong
    Human sparganosis is a rare disease often affecting muscle, subcutaneous tissue and other locations, but sparganosis invading the brain is rather rare. Cerebral sparganosis has no specific symptoms which makes the diagnosis quite difficult and is usually neglected in the clinic. Here the authors reported a case of a 29-year-old female who was diagnosed with cerebral sparganosis and underwent surgery in their department and a brief review of the literature was conducted as well. Read more
    Neuroimmunol Neuroinflammation 2017;4:238-42. | doi:10.20517/2347-8659.2017.16
    Published on: 20 Nov 2017  | Viewed:690  | Downloaded:7
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  • Case Report|Open Access

    A rare case of quadrigeminal plate lipoma presenting with the sixth cranial nerve palsy

    Bipin Kumar Chaurasia , Narendra Shalike , Silak Ram Chaudhary , Shamsul Alam , Dhiman Chowdhory , Kanak Kanti Barua , Ranjit Kumar Chaurasiya , Raushan Kumar Chaurasia , Ramesh Kumar Chaurasia , Tolga Dundar
    Intracranial lipomas are rare benign tumour that is slow growing, generally asymptomatic, most frequently located in the midline areas and are usually an incidental finding on imaging and therefore cases are not frequently reported. This study reports a case of a patient with quadrigeminal plate lipoma presenting with obstructive hydrocephalous and the 6th cranial nerve palsy that was successfully treated with ventriculo-peritoneal shunting without addressing the lesion. Read more
    Neuroimmunol Neuroinflammation 2017;4:232-5. | doi:10.20517/2347-8659.2017.40
    Published on: 9 Nov 2017  | Viewed:2063  | Downloaded:16
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  • Letter to Editor|Open Access

    Peripheral plasmablasts in anti-MuSK myasthenia gravis

    Guillermo Delgado-García , Teresa Corona-Vázquez
    Neuroimmunol Neuroinflammation 2017;4:236-7. | doi:10.20517/2347-8659.2017.39
    Published on: 9 Nov 2017  | Viewed:138  | Downloaded:9
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  • Case Report|Open Access

    Dramatic recovery from stroke following intravenous thrombolysis in a patient on prasugrel for recent percutaneous coronary angioplasty

    Salvadeeswaran Meenakshi-Sundaram , Palanikumar Subburamakrishnan , Jude Vinoth , Simon Victor Rajah Sanjeevi Madhan-Rajah , Somalinga Nagendran Karthik , Pandi Suresh
    The authors report the first case of thrombolysis in a patient already receiving both aspirin and prasugrel following a recent ischemic coronary event. A 55-year-old gentleman was treated for inferior wall myocardial infarction with aspirin, prasugrel and percutaneous angioplasty of right coronary artery. Three days following the procedure he developed acute ischemic stroke due to a left middle cerebral artery infarction with a National Institute of Health Stroke Scale (NIHSS) of 24 and was treated with alteplase. Therapy was interrupted after completion of 29 mg (for a body weight of 65... Read more
    Neuroimmunol Neuroinflammation 2017;4:216-8. | doi:10.20517/2347-8659.2016.57
    Published on: 19 Oct 2017  | Viewed:1426  | Downloaded:20
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  • Case Report|Open Access

    A case of atypical progressive multifocal encephalopathy mimicking acute ischemic stroke: case report and review of literature

    Maria Teresa Infante , Giovanni Novi , Riccarda Gentile , Laura Malfatto , Lucio Castellan , Carlo Serrati , Laura Barletta
    Progressive multifocal encephalopathy (PML) is a rare but often fatal infectious brain disease caused by the reactivation of John Cunningham polyomavirus. Reactivation occurs in immunocompromised individuals with AIDS and leukemia, on chemotherapy or being treated with immunosuppressant drugs (e.g. monoclonal antibodies). Cases of PML have been described in patients treated with natalizumab, efalizumab and rituximab used, respectively, for the treatment of (1) multiple sclerosis, (2) psoriasis and (3) haematological malignancies or systemic autoimmune diseases (rheumatoid arthritis and... Read more
    Neuroimmunol Neuroinflammation 2017;4:211-5. | doi:10.20517/2347-8659.2016.52
    Published on: 19 Oct 2017  | Viewed:1372  | Downloaded:11
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  • Original Article|Open Access

    LPS-induced TLR4 neuroinflammatory signaling in CHME-5 microglial cells

    Leandra K. Figueroa-Hall , Michael B. Anderson , Subhas Das , Craig W. Stevens , Randall L. Davis
    Aim: In the field of neuroinflammation, identifying specific effects of pharmacological agents and other factors is problematic given the relative difficulty and expense in obtaining and culturing primary microglia. Immortalized microglial cell lines are very useful, but only a limited number have been characterized for inflammatory signaling. Therefore, characterization of lipopolysaccharide (LPS)-induced toll-like receptor 4 (TLR4) signaling in CHME-5, a microglial cell line, is expected to be of value as an experimental model of inflammatory signaling in the central nervous system (CNS).... Read more
    Neuroimmunol Neuroinflammation 2017;4:219-31. | doi:10.20517/2347-8659.2017.38
    Published on: 19 Oct 2017  | Viewed:1415  | Downloaded:22
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  • Topic: Stroke|Open Access

    The roles of endoglin gene in cerebrovascular diseases

    Wan Zhu , Li Ma , Rui Zhang , Hua Su
    Endoglin (ENG, also known as CD105) is a transforming growth factor β (TGFβ) associated receptor and is required for both vasculogenesis and angiogenesis. Angiogenesis is important in the development of cerebral vasculature and in the pathogenesis of cerebral vascular diseases. ENG is an essential component of the endothelial nitric oxide synthase activation complex. Animal studies showed that ENG deficiency impairs stroke recovery. ENG deficiency also impairs the regulation of vascular tone, which contributes to the pathogenesis of brain arteriovenous malformation (bAVM) and vasospasm. In... Read more
    Neuroimmunol Neuroinflammation 2017;4:199-210. | doi:10.20517/2347-8659.2017.18
    Published on: 17 Oct 2017  | Viewed:1295  | Downloaded:30
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  • Original Article|Open Access

    Characteristics and predictive biomarkers of drug resistant epilepsy -- study in Georgia

    Maia Alkhidze , Giorgi Lomidze , Sofia Kasradze , Aleksander Tsiskaridze
    Aim: The authors conducted a case-control study to estimate predictive factors for timely identification of patients at higher risk for developing drug resistant epilepsy. Methods: The retrospective case-control study was conducted among people diagnosed as having drug resistant epilepsy (cases) and their controls, identified as having drug-responsive seizures. All participants were admitted to the tertiary Epilepsy Center at the Institute of Neurology and Neuropsychology (Tbilisi, Georgia) during 2011. The data on demographic features and disease characteristics were analyzed. Multiple... Read more
    Neuroimmunol Neuroinflammation 2017;4:191-8. | doi:10.20517/2347-8659.2017.14
    Published on: 27 Sep 2017  | Viewed:1890  | Downloaded:42
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  • Letter to Editor|Open Access

    Acute demyelinating lesions with restricted diffusion in multiple sclerosis: a new variant?

    Sofia Markoula , Anastassia Zikou , Persephoni Margariti , Maria Argyropoulou , Athanassios P. Kyritsis
    Neuroimmunol Neuroinflammation 2017;4:188-90. | doi:10.20517/2347-8659.2017.33
    Published on: 21 Sep 2017  | Viewed:357  | Downloaded:24
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  • Topic: Infectious Disease of Central Nervous System|Open Access

    Advancements in diagnosis and treatment of meningeal carcinomatosis in solid cancer

    Jun-Zhao Cui , Jun-Ying He , Qing Li , Xiao-Qing Li , Rui-Ping Gao , Hui Bu , Yue-Li Zou , Xiao-Su Guo , Wei-Xin Han , Ze-Yan Zhao , Yuan-Yuan Li , Ming-Ming Zheng , Ya-Juan Liu , Li-Tian Yan
    Meningeal carcinomatosis (MC) is a disease that malignant tumor cells cultivate in the cerebrospinal fluid or meninges. With the development of therapy methods and new techniques, survival time of patients with tumor is prolonged, and the incidence of MC is increasing. Diagnosis is based on the evaluation of clinical manifestations, cerebrospinal fluid and neuroimaging findings. Furthermore, in recent years, the diagnostic value of the tumor-derived cell-free DNA in the cerebrospinal fluid (CSF) is promising and may improve the diagnostic yield of CSF analysis. Traditional treatments of MC... Read more
    Neuroimmunol Neuroinflammation 2017;4:167-78. | doi:10.20517/2347-8659.2017.26
    Published on: 18 Sep 2017  | Viewed:1322  | Downloaded:38
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  • Original Article|Open Access

    Peripheral NK and B regulatory cell frequencies are altered with symptomatic exacerbation in generalized myasthenia gravis patients

    Xiao-Yin Lai , Meng-Cui Gui , Jing Lin , Yue Li , Xuan Luo , Long-Xuan Li , Bi-Tao Bu
    Aim: Myasthenia gravis (MG) is an autoimmune disease, in which immunotherapy can improve symptoms for a period, but the majority of patients still experience symptomatic fluctuation or develop myasthenic crisis. This study aimed to explore the relationship between frequency of peripheral lymphocyte subsets and myasthenia gravis disease stage. Methods: The percentages of B regulatory (Breg) cells and natural killer (NK) cells in the peripheral blood samples obtained from 54 MG patients and 10 healthy controls were surveyed using flow cytometry. MG patients were subdivided into the ocular MG,... Read more
    Neuroimmunol Neuroinflammation 2017;4:179-87. | doi:10.20517/2347-8659.2017.29
    Published on: 18 Sep 2017  | Viewed:2398  | Downloaded:50
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  • Topic: Stroke|Open Access

    Role of neuroinflammation in ischemic stroke

    Rui Liu , Meng-Xian Pan , Jun-Chun Tang , Ya Zhang , Hua-Bao Liao , Yang Zhuang , Dan Zhao , Qi Wan
    Ischemic stroke causes the depletion of energy and induce excitotoxicity and neuroinflammation in the brain that results from thrombotic blockage. Neuroinflammation occurs initially depending on activated resident microglia that has the same function as the macrophage. Activated microglia participates in the neuroinflammatory process by phagocytosing the injured brain cells and producing the pro- and anti-inflammatory mediators. In this review, the authors present an overview of the role of microglia in mediating neuroinflammation in ischemic stroke. Read more
    Neuroimmunol Neuroinflammation 2017;4:158-66. | doi:10.20517/2347-8659.2017.09
    Published on: 28 Aug 2017  | Viewed:3605  | Downloaded:173
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  • Case Report|Open Access

    Cytology abnormal of cerebrospinal fluid in superficial siderosis of the central nervous system

    Cui Wang , Jian-Xia Diao , Shu-Min Li
    Superficial siderosis of the central nervous system (SSCNS) is usually caused by chronic subarachnoid hemorrhage which leads to the accumulation of hemosiderin in the subpial layers of the brain and the spinal cord. The exact clinical manifestations and T2-weighted magnetic resonance imaging (MRI) the patient presented here is diagnosed SSCNS mainly due to the cytology of cerebrospinal fluid (CCSF) and the superficial siderosis of T2-weighted MRI. CCSF can be a good complementary to the diagnosis of SSCNS. Read more
    Neuroimmunol Neuroinflammation 2017;4:155-7. | doi:10.20517/2347-8659.2017.03
    Published on: 9 Aug 2017  | Viewed:1208  | Downloaded:47
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  • Topic: Stroke|Open Access

    Relationship of cerebral microbleeds to inflammatory marker levels

    Qiao-Li Lu , Chen Li , Ying Song , Liang Wang , Zhi-Rong Jia
    Aim: The purpose of this study is to investigate the incidence, distribution and risk factors of cerebral microbleeds (CMBs) and the relation between CMBs and inflammation in ischemic cerebrovascular disease. Methods: Two hundred and one patients without acute infarction or transient ischemic attack were enrolled. The presence and number of CMB were assessed on susceptibility-weighted imaging. The traditional risk factors of CMB were recorded. Levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and matrix metalloproteinase-9 (MMP-9) were tested. Logistic regression... Read more
    Neuroimmunol Neuroinflammation 2017;4:145-51. | doi:10.20517/2347-8659.2017.05
    Published on: 8 Aug 2017  | Viewed:1306  | Downloaded:58
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  • Editorial|Open Access

    Neurocysticercosis and hippocampal damage: a causal link favored by epileptogenesis or neuroinflammation?

    Oscar H. Del Brutto , Victor J. Del Brutto
    Neuroimmunol Neuroinflammation 2017;4:152-4. | doi:10.20517/2347-8659.2017.23
    Published on: 8 Aug 2017  | Viewed:680  | Downloaded:52
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Neuroimmunology and Neuroinflammation Print ISSN: 2347-8659; Online ISSN: 2349-6142
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