Latest
  • Case Report|Open Access

    Dramatic recovery from stroke following intravenous thrombolysis in a patient on prasugrel for recent percutaneous coronary angioplasty

    Salvadeeswaran Meenakshi-Sundaram , Palanikumar Subburamakrishnan , Jude Vinoth , Simon Victor Rajah Sanjeevi Madhan-Rajah , Somalinga Nagendran Karthik , Pandi Suresh
    The authors report the first case of thrombolysis in a patient already receiving both aspirin and prasugrel following a recent ischemic coronary event. A 55-year-old gentleman was treated for inferior wall myocardial infarction with aspirin, prasugrel and percutaneous angioplasty of right coronary artery. Three days following the procedure he developed acute ischemic stroke due to a left middle cerebral artery infarction with a National Institute of Health Stroke Scale (NIHSS) of 24 and was treated with alteplase. Therapy was interrupted after completion of 29 mg (for a body weight of 65... Read more
    Neuroimmunol Neuroinflammation 2017;4:216-8. | doi:10.20517/2347-8659.2016.57
    Published on: 19 Oct 2017  | Viewed:0  | Downloaded:0
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  • Case Report|Open Access

    A case of atypical progressive multifocal encephalopathy mimicking acute ischemic stroke: case report and review of literature

    Maria Teresa Infante , Giovanni Novi , Riccarda Gentile , Laura Malfatto , Lucio Castellan , Carlo Serrati , Laura Barletta
    Progressive multifocal encephalopathy (PML) is a rare but often fatal infectious brain disease caused by the reactivation of John Cunningham polyomavirus. Reactivation occurs in immunocompromised individuals with AIDS and leukemia, on chemotherapy or being treated with immunosuppressant drugs (e.g. monoclonal antibodies). Cases of PML have been described in patients treated with natalizumab, efalizumab and rituximab used, respectively, for the treatment of (1) multiple sclerosis, (2) psoriasis and (3) haematological malignancies or systemic autoimmune diseases (rheumatoid arthritis and... Read more
    Neuroimmunol Neuroinflammation 2017;4:211-5. | doi:10.20517/2347-8659.2016.52
    Published on: 19 Oct 2017  | Viewed:0  | Downloaded:0
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  • Topic: Stroke|Open Access

    The roles of endoglin gene in cerebrovascular diseases

    Wan Zhu , Li Ma , Rui Zhang , Hua Su
    Endoglin (ENG, also known as CD105) is a transforming growth factor β (TGFβ) associated receptor and is required for both vasculogenesis and angiogenesis. Angiogenesis is important in the development of cerebral vasculature and in the pathogenesis of cerebral vascular diseases. ENG is an essential component of the endothelial nitric oxide synthase activation complex. Animal studies showed that ENG deficiency impairs stroke recovery. ENG deficiency also impairs the regulation of vascular tone, which contributes to the pathogenesis of brain arteriovenous malformation (bAVM) and vasospasm. In... Read more
    Neuroimmunol Neuroinflammation 2017;4:199-210. | doi:10.20517/2347-8659.2017.18
    Published on: 17 Oct 2017  | Viewed:579  | Downloaded:12
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  • Original Article|Open Access

    Characteristics and predictive biomarkers of drug resistant epilepsy -- study in Georgia

    Maia Alkhidze , Giorgi Lomidze , Sofia Kasradze , Aleksander Tsiskaridze
    Aim: The authors conducted a case-control study to estimate predictive factors for timely identification of patients at higher risk for developing drug resistant epilepsy. Methods: The retrospective case-control study was conducted among people diagnosed as having drug resistant epilepsy (cases) and their controls, identified as having drug-responsive seizures. All participants were admitted to the tertiary Epilepsy Center at the Institute of Neurology and Neuropsychology (Tbilisi, Georgia) during 2011. The data on demographic features and disease characteristics were analyzed. Multiple... Read more
    Neuroimmunol Neuroinflammation 2017;4:191-8. | doi:10.20517/2347-8659.2017.14
    Published on: 27 Sep 2017  | Viewed:1422  | Downloaded:12
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  • Letter to Editor|Open Access

    Acute demyelinating lesions with restricted diffusion in multiple sclerosis: a new variant?

    Sofia Markoula , Anastassia Zikou , Persephoni Margariti , Maria Argyropoulou , Athanassios P. Kyritsis
    Neuroimmunol Neuroinflammation 2017;4:188-90. | doi:10.20517/2347-8659.2017.33
    Published on: 21 Sep 2017  | Viewed:175  | Downloaded:8
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  • Topic: Infectious Disease of Central Nervous System|Open Access

    Advancements in diagnosis and treatment of meningeal carcinomatosis in solid cancer

    Jun-Zhao Cui , Jun-Ying He , Qing Li , Xiao-Qing Li , Rui-Ping Gao , Hui Bu , Yue-Li Zou , Xiao-Su Guo , Wei-Xin Han , Ze-Yan Zhao , Yuan-Yuan Li , Ming-Ming Zheng , Ya-Juan Liu , Li-Tian Yan
    Meningeal carcinomatosis (MC) is a disease that malignant tumor cells cultivate in the cerebrospinal fluid or meninges. With the development of therapy methods and new techniques, survival time of patients with tumor is prolonged, and the incidence of MC is increasing. Diagnosis is based on the evaluation of clinical manifestations, cerebrospinal fluid and neuroimaging findings. Furthermore, in recent years, the diagnostic value of the tumor-derived cell-free DNA in the cerebrospinal fluid (CSF) is promising and may improve the diagnostic yield of CSF analysis. Traditional treatments of MC... Read more
    Neuroimmunol Neuroinflammation 2017;4:167-78. | doi:10.20517/2347-8659.2017.26
    Published on: 18 Sep 2017  | Viewed:1080  | Downloaded:23
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  • Original Article|Open Access

    Peripheral NK and B regulatory cell frequencies are altered with symptomatic exacerbation in generalized myasthenia gravis patients

    Xiao-Yin Lai , Meng-Cui Gui , Jing Lin , Yue Li , Xuan Luo , Long-Xuan Li , Bi-Tao Bu
    Aim: Myasthenia gravis (MG) is an autoimmune disease, in which immunotherapy can improve symptoms for a period, but the majority of patients still experience symptomatic fluctuation or develop myasthenic crisis. This study aimed to explore the relationship between frequency of peripheral lymphocyte subsets and myasthenia gravis disease stage. Methods: The percentages of B regulatory (Breg) cells and natural killer (NK) cells in the peripheral blood samples obtained from 54 MG patients and 10 healthy controls were surveyed using flow cytometry. MG patients were subdivided into the ocular MG,... Read more
    Neuroimmunol Neuroinflammation 2017;4:179-87. | doi:10.20517/2347-8659.2017.29
    Published on: 18 Sep 2017  | Viewed:1537  | Downloaded:31
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  • Topic: Stroke|Open Access

    Role of neuroinflammation in ischemic stroke

    Rui Liu , Meng-Xian Pan , Jun-Chun Tang , Ya Zhang , Hua-Bao Liao , Yang Zhuang , Dan Zhao , Qi Wan
    Ischemic stroke causes the depletion of energy and induce excitotoxicity and neuroinflammation in the brain that results from thrombotic blockage. Neuroinflammation occurs initially depending on activated resident microglia that has the same function as the macrophage. Activated microglia participates in the neuroinflammatory process by phagocytosing the injured brain cells and producing the pro- and anti-inflammatory mediators. In this review, the authors present an overview of the role of microglia in mediating neuroinflammation in ischemic stroke. Read more
    Neuroimmunol Neuroinflammation 2017;4:158-66. | doi:10.20517/2347-8659.2017.09
    Published on: 28 Aug 2017  | Viewed:2699  | Downloaded:143
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  • Case Report|Open Access

    Cytology abnormal of cerebrospinal fluid in superficial siderosis of the central nervous system

    Cui Wang , Jian-Xia Diao , Shu-Min Li
    Superficial siderosis of the central nervous system (SSCNS) is usually caused by chronic subarachnoid hemorrhage which leads to the accumulation of hemosiderin in the subpial layers of the brain and the spinal cord. The exact clinical manifestations and T2-weighted magnetic resonance imaging (MRI) the patient presented here is diagnosed SSCNS mainly due to the cytology of cerebrospinal fluid (CCSF) and the superficial siderosis of T2-weighted MRI. CCSF can be a good complementary to the diagnosis of SSCNS. Read more
    Neuroimmunol Neuroinflammation 2017;4:155-7. | doi:10.20517/2347-8659.2017.03
    Published on: 9 Aug 2017  | Viewed:1026  | Downloaded:35
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  • Topic: Stroke|Open Access

    Relationship of cerebral microbleeds to inflammatory marker levels

    Qiao-Li Lu , Chen Li , Ying Song , Liang Wang , Zhi-Rong Jia
    Aim: The purpose of this study is to investigate the incidence, distribution and risk factors of cerebral microbleeds (CMBs) and the relation between CMBs and inflammation in ischemic cerebrovascular disease. Methods: Two hundred and one patients without acute infarction or transient ischemic attack were enrolled. The presence and number of CMB were assessed on susceptibility-weighted imaging. The traditional risk factors of CMB were recorded. Levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and matrix metalloproteinase-9 (MMP-9) were tested. Logistic regression... Read more
    Neuroimmunol Neuroinflammation 2017;4:145-51. | doi:10.20517/2347-8659.2017.05
    Published on: 8 Aug 2017  | Viewed:1142  | Downloaded:43
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  • Editorial|Open Access

    Neurocysticercosis and hippocampal damage: a causal link favored by epileptogenesis or neuroinflammation?

    Oscar H. Del Brutto , Victor J. Del Brutto
    Neuroimmunol Neuroinflammation 2017;4:152-4. | doi:10.20517/2347-8659.2017.23
    Published on: 8 Aug 2017  | Viewed:603  | Downloaded:44
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  • Topic: Infectious Disease of Central Nervous System|Open Access

    Developments in auxiliary examination of Creutzfeldt-Jakob disease

    Wei Zhao , Jiao-Jiao Jiang , Jia-Tang Zhang
    Creutzfeldt-Jakob disease (CJD), which is caused by prion scrapie protein, is a rare, chronic, transmissible and fatal disease. Clinical manifestations of CJD include rapidly progressive dementia, cerebellar ataxia, visual disturbance, as well as pyramidal and extrapyramidal tract signs. Four subtypes of CJD have been reported, including sporadic, familial or genetic, iatrogenic and variant. Given the infectiousness and high mortality of the disease, it is imperative that earlier and more accurate diagnostic methods are developed. In the past years, 14-3-3 protein testing and periodic sharp... Read more
    Neuroimmunol Neuroinflammation 2017;4:136-44. | doi:10.20517/2347-8659.2017.01
    Published on: 21 Jul 2017  | Viewed:765  | Downloaded:63
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  • Original Article|Open Access

    Analysis of clinical data of viral encephalitis patients complicated with epilepsy during the acute phase

    Shi-Ying Chen , Wei Ma , Yan-Yan Chen , Xue-Wen Fan
    Aim: To compare the difference between viral encephalitis patients complicated with epilepsy group and those without epilepsy. Methods: The authors retrospectively study 116 cases of viral encephalitis patients admitted to the General Hospital of Ningxia Medical University and the Cardia-Cerebrovascular Disease Hospital of Ningxia Medical University from January 2011 to December 2016. There were 39 cases with epilepsy and 77 cases without epilepsy. By surveying the Hospital Information System, the authors collected their clinical data including general situations, medical history, physical... Read more
    Neuroimmunol Neuroinflammation 2017;4:124-31. | doi:10.20517/2347-8659.2017.17
    Published on: 11 Jul 2017  | Viewed:2005  | Downloaded:79
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  • Commentary|Open Access

    Hot topics of autoimmune encephalitis

    Ying Peng , Jia-Wei Wang
    Neuroimmunol Neuroinflammation 2017;4:132-5. | doi:10.20517/2347-8659.2016.50
    Published on: 11 Jul 2017  | Viewed:750  | Downloaded:105
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  • Review|Open Access

    The association between human cytomegalovirus and glioblastomas: a review

    Christian B. Hochhalter , Christopher Carr , Brannan E. O’Neill , Marcus L. Ware , Michael J. Strong
    Human cytomegalovirus (HCMV) was reported in glioblastoma multiforme (GBM) over a decade ago and this finding has the potential to increase our understanding of the disease and it offers an alternative tumor-specific therapeutic target. Due of this promise, there is a fair amount of time, energy and money being directed towards understanding and utilizing this connection for eventual therapeutic purposes. Nevertheless, the association between GBM and HCMV remains controversial. Several studies have reported conflicting results, further undermining the potential clinical value of this... Read more
    Neuroimmunol Neuroinflammation 2017;4:96-108. | doi:10.20517/2347-8659.2017.10
    Published on: 16 Jun 2017  | Viewed:2982  | Downloaded:146
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  • Minireview|Open Access

    How are necroptosis, immune dysfunction, and motoneuron death connected in amyotrophic lateral sclerosis?

    Jian-Feng Liu , Ou-Xiang Zheng , Jun-Guo Xin , Hannah H. Chen , John J. Xin
    Abnormal immune response/inflammation is present in patients of amyotrophic lateral sclerosis (ALS). Autoimmune-related inflammation has been thought to be involved in the pathogenesis of ALS. However, how the abnormal immune responses are initiated, what specific immune cells and how these immune cells are involved in this disease have not been well understood. This is partly owing to two facts of ALS: late diagnosis and chronic nature. The late diagnosis makes it difficult to conclude whether the abnormal immune responses/inflammation is the cause or result of the disease. The chronic... Read more
    Neuroimmunol Neuroinflammation 2017;4:109-16. | doi:10.20517/2347-8659.2017.12
    Published on: 16 Jun 2017  | Viewed:1530  | Downloaded:109
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  • Case Report|Open Access

    Thymoma-associated panencephalitis: a newly emerging paraneoplastic neurologic syndrome

    Lynda Adaobi Nwabuobi , Jacob Christian Pellinen , Thomas Mark Wisniewski
    Recently, a few case reports of thymoma-associated panencephalitis (TAPE) have brought to light a disease entity that has not been fully characterized. Literature review of TAPE reveals an array of associated neuronal antibodies, with varied responses to thymomectomy with or without immunotherapy. This report describes a case of TAPE and proposes that the GABAA receptor antibody is a potential target antigen driving the immune process in this disease entity. Treatment-wise, early thymomectomy consistently improves the overall course of disease. Further study of such cases will be critical... Read more
    Neuroimmunol Neuroinflammation 2017;4:117-23. | doi:10.20517/2347-8659.2016.53
    Published on: 16 Jun 2017  | Viewed:578  | Downloaded:44
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  • Case Report|Open Access

    Miller-Fisher syndrome after etanercept

    Elena Grebenciucova , John H. Pula
    The authors describe a case of Miller-Fischer syndrome, a rare demyelinating syndrome, preceded by a viral prodrome and three doses of etanercept, an anti-tumor necrosis factor α (anti-TNFα) agent. Anti-TNFα agents are associated with an induction of episodes of demyelination and may unmask multiple sclerosis in those who are immunogenetically predisposed. Read more
    Neuroimmunol Neuroinflammation 2017;4:93-5. | doi:10.20517/2347-8659.2016.48
    Published on: 23 May 2017  | Viewed:618  | Downloaded:77
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  • Topic: Stroke|Open Access

    When friend turns foe: central and peripheral neuroinflammation in central nervous system injury

    Paul Marcet , Nicole Santos , Cesar V. Borlongan
    Injury to the central nervous system (CNS) is common, and though it has been well studied, many aspects of traumatic brain injury (TBI) and stroke are poorly understood. TBI and stroke are two pathologic events that can cause severe, immediate impact to the neurostructure and function of the CNS, which has been recognized recently to be exacerbated by the body’s own immune response. Although the brain damage induced by the initial trauma is most likely unsalvageable, the secondary immunologic deterioration of neural tissue gives ample opportunity for therapeutic strategists seeking to... Read more
    Neuroimmunol Neuroinflammation 2017;4:82-92. | doi:10.20517/2347-8659.2017.07
    Published on: 17 May 2017  | Viewed:1886  | Downloaded:143
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  • Case Report|Open Access

    A case report of anti-N-methyl-d-aspartate receptor autoimmune encephalitis with sensory attack. Is limbic encephalitis only “limbic”?

    Sheng Chen , Xiao-Jie Zhang , Meng-Sha Yao , Xing-Hua Luan , Fei Yuan , Jun Liu , Shu-Feng Chen , Chen-Fei Jia , Sheng-Di Chen
    To emphasize the early diagnosis and treatment of anti-N-methyl-d-aspartate-receptor (NMDAR) autoimmune encephalitis, a rare clinical condition, teratoma-related, anti-NMDAR encephalitis should be suspected if young patients present with psychiatric, movement, and sensory symptoms. Early diagnosis and treatment can decrease the mortality and disability rate. Read more
    Neuroimmunol Neuroinflammation 2017;4:78-81. | doi:10.20517/2347-8659.2016.39
    Published on: 10 May 2017  | Viewed:1549  | Downloaded:66
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Neuroimmunology and Neuroinflammation Print ISSN: 2347-8659; Online ISSN: 2349-6142
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