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  • Topic: Infectious Disease of Central Nervous System

    A review with comments on herpes simplex encephalitis in adults

    Xu-Zheng Zuo , Wei-Ju Tang , Xiu-Ying Chen , Wen Huang
    Herpes simplex encephalitis (HSE) can cause permanent injury to the brain parenchyma. As such, it is usually treated as a medical emergency for which correct immediate diagnosis and introduction of specific therapies are critical for survival and prognosis. Here, the authors review the current status of diagnosis and treatments and discuss unsolved issues surrounding therapeutic interventions. The authors also highlight the current expectations for future management of HSE.
    Published on: 20 Feb 2017
    Views: 527
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  • Original Article

    Meningeal carcinomatosis: a retrospective analysis of seventy-seven cases

    Feng-Na Chu , Yue Lang , Xiao-Min Sun , Li Cui
    Aim: Meningeal carcinomatosis is a special type of malignant tumor characterized by short survival and poor prognosis. In the present study, the authors aim to analyze the clinical, laboratory data and prognosis of meningeal carcinomatosis patients. Methods: The authors enrolled 77 cases of meningeal carcinomatosis from 2003 to 2013 in the First Hospital of Jilin University. The clinical data including age, gender, symptoms at onset, clinical manifestations, primary tumors and the laboratory data including cerebrospinal fluid (CSF), tumor markers as well as the imaging data were analyzed....
    Published on: 20 Jan 2017
    Views: 471
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  • Case Report

    Parasellar extra-axial cavernoma mimicking meningioma: a case report

    Arun Oommen , Thara Pratap , Sushil Chandi , Muhammed Jasim Abdul Jalal
    Parasellar extra-axial cavernomas are rare lesions. The authors report a case of extra-axial cavernoma in a 50-year-old male patient, who presented with occipital headache and double vision. The magnetic resonance imaging showed an enhancing extra-axial dural-based mass in the left parasellar region invading cavernous sinus, hyper-intense on T2-weighted images, iso-intense on T1-weighted images and high relative cerebral blood velocity on magnetic resonance perfusion. The patient underwent a left pterional craniotomy and parasellar space occupying lesion was excised. Histopathology was...
    Published on: 20 Jan 2017
    Views: 456
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  • Original Article

    Single low-dose lipopolysaccharide preconditioning: neuroprotective against axonal injury and modulates glial cells

    Ryan C. Turner , Zachary J. Naser , Brandon P. Lucke-Wold , Aric F. Logsdon , Reyna L. Vangilder , Rae R. Matsumoto , Jason D. Huber , Charles L. Rosen
    Aim: Over 7 million traumatic brain injuries (TBI) are reported each year in the United States. However, treatments and neuroprotection following TBI are limited because secondary injury cascades are poorly understood. Lipopolysaccharide (LPS) administration before controlled cortical impact can contribute to neuroprotection. However, the underlying mechanisms and whether LPS preconditioning confers neuroprotection against closed-head injuries remains unclear. Methods: The authors hypothesized that preconditioning with a low dose of LPS (0.2 mg/kg) would regulate glial reactivity and...
    Published on: 20 Jan 2017
    Views: 439
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  • Case Report

    Reversible posterior leukoencephalopathy syndrome: single photon emission computerized tomography observations

    Salvadeeswaran Meenakshi-Sundaram , Sathyam Senthilnathan , Kaliappan Gurusamy Srinivasan , Somalinga Nagendran Karthik , Pandi Suresh , Somasundaram Palanirajan
    The authors report clinical correlations of single photon emission computerized tomography (SPECT) findings in reversible posterior leukoencephalopathy (RPL). These are observations that have not received wide attention in literature. A 31-year-old hypertensive gentleman, on discontinuing antihypertensive medications, presented with vomiting, headache, focal motor to bilateral tonic-clonic seizures, altered sensorium, right gaze palsy and right hemiparesis. Accelerated hypertension was noted and he improved well with antihypertensive and anticonvulsant therapy. While cranial magnetic...
    Published on: 20 Feb 2017
    Views: 303
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  • Original Article

    Prenatal zinc supplementation to lipopolysaccharide infected female rats prevents neurochemical, behavioral and biochemical deficits produced in infants

    Neha Sharma , Palvi Arora , Bimla Nehru
    Aim: Recent research revealed an association between maternal infection i.e. lipopolysaccharide (LPS) exposure during pregnancy and increased risk for central nervous system disorders being passed onto the off-spring. Therefore, the present study was designed to investigate the effect of LPS infection during d14-17 of pregnancy (equivalent to third trimester in humans) on neurochemical, neurobehavioral abnormalities, biochemical as well as histopathological parameters in male/female pups. Also, the effect of zinc supplementation throughout pregnancy to female rats in ameliorating LPS...
    Published on: 21 Mar 2017
    Views: 252
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  • Guidelines

    Treatment guidelines of chronic inflammatory demyelinating polyneuropathy in China

    Li-Ying Cui , Chuan-Qiang Pu , Xue-Qiang Hu
    Chronic inflammatory demyelinating polyradiculoneuropathy, or chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated inflammatory disorder at the peripheral nervous system, in which the progression is chronic and also remission relapse. In most cases, it is also associated with cerebrospinal fluid (CSF) protein-cell separation. Electrophysiologically, the peripheral nerve conduction velocity decreases, blocks and characterized as discrete abnormal waveform. Pathologically, there is also multifocal demyelination of myelinated fibers, nerve endometrial edema,...
    Published on: 20 Feb 2017
    Views: 226
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  • Topic: Ischemic Stroke

    Cerebral ischemia at early postoperative period of direct revascularization for moyamoya disease: a case report and literature review

    Xiao-Lin Chen , Li Ma , Yu Chen , Jun-Lin Lu , Xun Ye , Rong Wang , Yuan-Li Zhao
    Hypoperfusion and hyperperfusion could be causes of early postoperative complications that lead to neurological deterioration in patients with moyamoya diseases (MMD) after superficial temporal artery (STA) and middle cerebral artery (MCA) anastomosis. Here, the authors described a case of child-onset bilateral MMD that manifested transient cerebral ischemia in the contralateral hemisphere after left STA-MCA bypass in young adulthood. A new onset of cerebral ischemia in the contralateral hemisphere and transient neurological deterioration suggested the fragile hemodynamics of MMD during...
    Published on: 24 Mar 2017
    Views: 121
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