Topic: The Metabolic-Inflammatory Mechanisms in Brain Aging and Neurodegenerative Disorders
A special issue of Neuroimmunology and Neuroinflammation (Print ISSN：2347-8659; Online ISSN：2349-6142).
Deadline for manuscript submissions: 20 Apr 2018
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- Prof. Jerzy Leszek, MD, PhD
- Professor of Psychiatry, Vice-Head of the Department of Psychiatry; Head of Alzheimer’s Disease Lab at the Medical University in Wroclaw, and Scientific Director of Alzheimer’s Disease Center in Scinawa near Wroclaw, Poland.
Special Issue Introduction:
Neuroinflammatory responseis primarily a protective mechanism in the brain. However, excessive and chronic inflammatory responses can lead to deleterious effects involving immune cells, brain cells and signaling molecules. Neuroinflammation induces and accelerates pathogenesis of neurodegeneration disorders like Alzheimer’s disease (AD), Parkinson disease (PD) or Multiple sclerosis (MS). The sustained release of inflammatory mediators works to perpetuate the inflammatory cycle, activating additional microglia, promoting their proliferation, and resulting in further release of inflammatory factors. Interaction between activated glia and neurons around ABeta plaques maintain a chronic, self-sustaining inflammatory state in affected brain. An importance topic to address is the use of neuropharmacological-driven approaches that could attenuate neuroinflammatory processes in the diseases brain and improve the outcome. In this special issue for Neuroimmunology and Neuroinflammation we will discuss about the link between metabolic disorders and dementia risk. This has raised new questions about specific mechanisms underlying these associations that have critical implications for the way we define and classify dementias. Activation of pro and anti-inflammatory signaling cascades, metabolic impairment, production of reactive species, excitatory mediators or downregulation of growth factors may lead to the development of CNS injuries in neurodegenerative disorders. Thus, our special issue will focus on up-to-date research targeting these pathways and mediators upon CNS damage.
Subtopics of interest include but are NOT limited to:
Neurobiology of disease
Keywords: Neuroinflammation, metabolic impairment, mitochondrial dysfunction, oxidative stress, apoptosis, autophagy
This special issue is now open for submission.
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