Topic: Neurovascular and neuroinflammation mechanisms associated with bipolar disorder

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A special issue of Neuroimmunology and Neuroinflammation  (Print ISSN:2347-8659; Online ISSN:2349-6142).

Deadline for manuscript submissions: 14 Jun 2015

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Guest Editor(s)

  • Dr. Gianfranco Spalletta, MD, PhD
    Neuropsychiatry Laboratory, Department of Clinical and Behavioral Neurology, Scientific Institute for Research, Hospitalisation and Health Care Santa Lucia Foundation, Rome, Italy.

    Website | E-mail

Submission Information:

For Author Instructions, please refer to
For Online Submission, please login at
Submission Deadline: 14 Jun 2015
Contacts: Ruirui Zhang, Managing Editor,

Published Articles Download All Articles
  • Neurovascular and neuroinflammatory mechanisms associated with mood disorders

    Gianfranco Spalletta , Gabriele Sani
    Neuroimmunol Neuroinflammation 2015;2:193-4. | doi:10.4103/2347-8659.167306
    Published on: 15 Oct 2015  | Viewed:4203  | Downloaded:171
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  • Bipolar disorder preceding the onset of multiple sclerosis

    Ciro Marangoni , Maria Giulia Nanni , Luigi Grassi , Gianni M. Faedda
    Multiple sclerosis (MS) is the most common inflammatory demyelinating brain disease. The occurrence of psychiatric disorders, especially for major depression, in the course of MS is high. Reports concerning bipolar disorder (BD) remain rather scarce although early descriptions were found in the old neurological literature. The purpose of this article is to provide a critical review of the... Read more
    Neuroimmunol Neuroinflammation 2015;2:195-9. | doi:10.4103/2347-8659.167302
    Published on: 15 Oct 2015  | Viewed:7981  | Downloaded:224
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  • Microstructural brain abnormalities, affective temperaments, and suicidal behavior in patients with major depression

    Gianluca Serafini , Mario Amore , Zoltan Rihmer
    According to magnetic resonance imaging (MRI) studies, brain white matter (WM) abnormalities have been suggested to play a critical role in the pathogenesis of major depressive disorder (MDD) and related suicidal behavior. However, MRI findings may be limited by low spatial resolution; therefore, an important contribution to the understanding of the role and significance of WM alterations... Read more
    Neuroimmunol Neuroinflammation 2015;2:200-14. | doi:10.4103/2347-8659.167301
    Published on: 15 Oct 2015  | Viewed:4534  | Downloaded:178
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  • Neuroinflammation and excitatory symptoms in bipolar disorder

    Isabella Panaccione , Gianfranco Spalletta , Gabriele Sani
    Neuroinflammation has been proposed as a strong biological factor underlying the development of neuropsychiatric diseases. A role for dysregulation of the immune system was initially suggested in depressive disorders and subsequently extended to other illnesses, including bipolar disorder (BD). Indeed, there is growing evidence confirming the presence of a generalized pro‑inflammatory state in... Read more
    Neuroimmunol Neuroinflammation 2015;2:215-27. | doi:10.4103/2347-8659.167304
    Published on: 15 Oct 2015  | Viewed:5484  | Downloaded:204
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  • Psychotic and nonpsychotic mood disorders in autoimmune encephalitis: diagnostic issues and research implications

    Giuseppe Quaranta , Nunzio Bucci , Cristina Toni , Giulio Perugi
    Recent research on autoimmune disorders suggests additional links between systemic and central nervous system (CNS) pathophysiology, among which the identification of antibody-induced limbic encephalitis provided the strongest evidence for the potential involvement of autoimmunity in the pathogenesis of severe mood and psychotic symptoms. In these illnesses, psychiatric symptoms predominate in... Read more
    Neuroimmunol Neuroinflammation 2015;2:228-36. | doi:10.4103/2347-8659.160986
    Published on: 15 Oct 2015  | Viewed:9191  | Downloaded:339
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  • The role of anti-glutamic acid decarboxylase autoantibodies in mood disorders

    Marco Liguori , Mirko Manchia , Leonardo Tondo
    Gamma-aminobutyric acid (GABA) possibly plays a causative role in mood disorders. This hypothesis originated with studies on the beneficial effect of valproate in mania and as a mood stabilizer. Since valproate is known for its action in increasing the level of GABA, it was indirectly suggested that decreasing levels of GABA were responsible for mood alterations. To identify factors causing the... Read more
    Neuroimmunol Neuroinflammation 2015;2:237-43. | doi:10.4103/2347-8659.167300
    Published on: 15 Oct 2015  | Viewed:5995  | Downloaded:219
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  • The role of neuroinflammation in juvenile bipolar disorder

    Giulia Serra , Lavinia De Chiara , Ciro Marangoni , Gianni L. Faedda
    A pathophysiological relationship has been reported between inflammatory processes, decreased levels of neurotrophins, increased oxidative stress and psychiatric disorders in both juvenile and adult ages. Moreover, this relationship remains unclear in juvenile bipolar disorder (BD). We performed a systematic literature review of studies reporting measurements of inflammatory markers, oxidative... Read more
    Neuroimmunol Neuroinflammation 2015;2:244-51. | doi:10.4103/2347-8659.167303
    Published on: 15 Oct 2015  | Viewed:6739  | Downloaded:126
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  • Neuroinflammation in bipolar disorders

    Georgios D. Kotzalidis , Elisa Ambrosi , Alessio Simonetti , Ilaria Cuomo , Antonio Del Casale , Matteo Caloro , Valeria Savoja , Chiara Rapinesi
    Recent literature based on peripheral immunity findings speculated that neuroinflammation, with its connection to microglial activation, is linked to bipolar disorder. The endorsement of the neuroinflammatory hypotheses of bipolar disorder requires the demonstration of causality, which requires longitudinal studies. We aimed to review the evidence for neuroinflammation as a pathogenic mechanism... Read more
    Neuroimmunol Neuroinflammation 2015;2:252-62. | doi:10.4103/2347-8659.167309
    Published on: 15 Oct 2015  | Viewed:5373  | Downloaded:405
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Neuroimmunology and Neuroinflammation ISSN 2349-6142 (Online), ISSN 2347-8659 (Print)
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