Topic: Autoimmune neurological diseases associated with autoantibodies specific for synaptic antigens

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A special issue of Neuroimmunology and Neuroinflammation  (Print ISSN:2347-8659; Online ISSN:2349-6142).

Deadline for manuscript submissions: 3 Oct 2015

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Guest Editor(s)

  • Dr. Raffaele Iorio
    Institute of Neurology, Department of Neuroscience, Catholic University, Rome, Italy.

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Submission Information:

For Author Instructions, please refer to http://nnjournal.net/pages/view/author_instructions
For Online Submission, please login at http://www.editorialmanager.com/neurimm/default.aspx
Submission Deadline: 3 Oct 2015
Contacts: Ruirui Zhang, Managing Editor, editor001@nnjournal.net

Published Articles Download All Articles
  • Autoimmune encephalopathies in children: diagnostic clues and therapeutic challenges

    Giorgia Olivieri , Ilaria Contaldo , Gloria Ferrantini , Elisa Musto , Roberta Scalise , Maria Chiara Stefanini , Domenica Battaglia , Eugenio Mercuri
    Neuronal surface antibody syndromes (NSAS) encompass a variety of disorders associated with “neuronal surface antibodies”. These share clinical and neuroradiological features that pose challenges related to their recognition and treatment. Recent epidemiological studies show a clear predominance for the glutamate-N-methyl-D-aspartate receptor encephalitis in both adults and pediatric population. Despite this, the overall NSAS’s incidence remains underestimated, and diagnosis persists to be not always easy to achieve. Based on current literature data, in this paper the authors propose a... Read more
    Neuroimmunol Neuroinflammation 2016;3:147-55. | doi:10.20517/2347-8659.2016.09
    Published on: 8 Jul 2016  | Viewed:9607  | Downloaded:621
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  • Diagnostic algorithms in autoimmune encephalitis

    Valentina Damato
    Over the past decade the discovery of novel forms of encephalitis associated with neuronal surface antibodies had changed the paradigms for diagnosing and treating disorders that were previously mischaracterized. Recognition of clinical syndromes, consistent methods of diagnosis, and early targeted immunotherapy can lead to a favorable outcome in diseases that may be associated with significant disability or death if left untreated. Here the conditions associated with neuronal surface antibodies are briefly reviewed, some general aspects of these syndromes are considered and guidelines that... Read more
    Neuroimmunol Neuroinflammation 2016;3:93-7. | doi:10.20517/2347-8659.2015.43
    Published on: 19 Apr 2016  | Viewed:11886  | Downloaded:799
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  • Neurological diseases associated with autoantibodies targeting the voltage-gated potassium channel complex: immunobiology and clinical characteristics

    Domenico Plantone , Rosaria Renna , Tatiana Koudriavtseva
    Voltage-gated potassium channels (VGKCs) represent a group of tetrameric signaling proteins with several functions, including modulation of neuronal excitability and neurotransmitter release. Moreover, VGKCs give a key contribution to the generation of the action potential. VGKCs are complexed with other neuronal proteins, and it is now widely known that serum autoantibodies directed against VGKCs are actually directed against the potassium channel subunits only in a minority of patients. By contrast, these autoantibodies more commonly target three proteins that are complexed with... Read more
    Neuroimmunol Neuroinflammation 2016;3:69-78. | doi:10.4103/2347-8659.169883
    Published on: 28 Mar 2016  | Viewed:22896  | Downloaded:511
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  • Encephalitis associated with autoantibody binding to the anti-N-methyl-D-aspartate receptor: immunopathogenesis, mechanisms, and clinical characteristics

    Adhasit Nawa-apisak , Saharat Aungsumart , Metha Apiwattanakul
    Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis has been increasingly recognized in recent years. This condition may be the most common cause of antibody-mediated encephalitis worldwide. The majority of patients are young at the time of onset, female, and present with an acute-to-subacute onset of behavioral changes followed by seizure, abnormal movement, autonomic dysfunction, and finally hypoventilation with coma if left untreated. The immunopathogenesis of this disease may be due to antibody-mediated internalization of NMDARs from synapses, which results in the dysfunction of... Read more
    Neuroimmunol Neuroinflammation 2016;3:79-85. | doi:10.4103/2347-8659.169913
    Published on: 28 Mar 2016  | Viewed:4507  | Downloaded:226
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  • Encephalitis associated with autoantibodies binding to γ-aminobutyric acid-A, γ-aminobutyric acid-B and glycine receptors: immunopathogenic mechanisms and clinical characteristics

    Amy May Lin Quek , Orna O'Toole
    Recent, discoveries of neural antibodies have facilitated the diagnosis of immune-mediated, immunotherapy-responsive neurologic disorders. Antibodies that target inhibitory central nervous system receptors, such as γ-aminobutyric acid-B, γ-aminobutyric acid-A, and glycine receptors, disrupt inhibitory regulatory synaptic functions, and lead to neuronal hyperexcitability. The myriad of neurologic, manifestations associated with these antibodies includes seizures, encephalopathy, muscle rigidity and stiffness. This article provides a review of the immunopathogenic mechanisms and the clinical... Read more
    Neuroimmunol Neuroinflammation 2016;3:86-92. | doi:10.4103/2347-8659.170633
    Published on: 28 Mar 2016  | Viewed:4864  | Downloaded:287
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Neuroimmunology and Neuroinflammation Print ISSN: 2347-8659; Online ISSN: 2349-6142
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