- Dr. Daniele Orsucci, MD
- Unit of Neurology, San Luca Hospital, Lucca, Italy.
Special Issue Introduction
The pathogenesis of Alzheimer's disease (AD) is complex, and only a minority of cases appears to be primarily genetic. A relationship between genetic and acquired factors in AD has been hypothesized. Many vascular risk factors for AD could result in cerebrovascular dysfunction. Oxidative damage and mitochondrial dysfunction have been also implicated in the pathogenesis of AD, but the question as to whether they are involved in the onset and progression of the pathology or rather represent a consequence of neurodegeneration is still debatable. Recent evidence suggests that an abnormal inflammatory response may have a pivotal role. This special issue discusses the role of neuroinflammation in AD, focusing on the mechanisms that lead to vascular dysfunction, mitochondrial dysfunction, oxidative stress and neurodegeneration, a "vicious circle" that ends in dementia.
KeywordsAlzheimer, Alzheimer's disease, inflammation, neurodegeneration, neuroinflammation
Submission Deadline31 Jul 2020