- Prof. Toshihide Yamashita
- Department of Molecular Neuroscience, Graduate School of Medicine, University of Osaka, Suita, Osaka, Japan.
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- Dr. Wael Mohamed
- Department of Basic Medical Science, International Islamic University Malaysia, Selayang, Malaysia.
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Special Issue Introduction
The central nervous system (CNS) blood vessels are continuous and non-fenestrated, which possess a variety of additional properties that allow them to closely control the flow of molecules , ions, and cells between the blood and the CNS. This extreme restriction helps BBB endothelial cells to tightly control the CNS homeostasis needed for proper neuronal function, as well as to protect the CNS from toxins, parasites, inflammation, injury and disease. This special issue explores the role of altered BBB in various neuroinflammatory conditions such as MS and neurodegenerative disorders. In addition, various methods that modulate or bypass BBB for the delivery of therapeutics with emerging novel therapies available will be addressed.
1. Brain ischemia and vascular ischemia in human and animal models
2. Stroke and neuroinflammation
3. Neuroinflammation and neurodegenerative disorders in human and animal models
4. Roles of natural compounds in brain neuroprotection and treatment of neuroinflammation
5. Corona virus and brain neuroinflammation or neurological damage
6. Microglia and BBB
7. Multiple sclerosis and neuroinflammation
8. The role of gut microbiome in neuroinflammation
9. Oxidative stress and mitochondrial dysfunction and neuroinflammation
10. Translational Animal model of neuroinflammation
11. Neuroinflammation as a pathological mechanism for various neurological disorders such as epilepsy, PD, and AD
Submission Deadline30 Nov 2021