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    Review| Open Access

    CAR-T cell therapy in neuro-oncology: applications and toxicity

    Akanksha Sharma, Gustavo De Leon, Alyx Porter, Marie F Grill, Allison Rosenthal, Christine E Brown, Kristin Swanson, Maciej M Mrugala

    A new era for cancer treatment has been ushered in with the field of cancer immunotherapy. After initial success with systemic malignancies, several of these promising treatments are being investigated for efficacy with primary and secondary brain tumors. Chimeric antigen receptor (CAR) T cells... Read more

    This article belongs to the Special Issue Immunotherapeutic Approaches for Treatment of Brain Tumors Neuroimmunol Neuroinflammation 2018;5:43. | doi:10.20517/2347-8659.2018.51
    Published on: 18 Oct 2018  | Viewed:5  | Downloaded:0
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    Review| Open Access

    It takes two: potential therapies and insights involving microglia and macrophages in glioblastoma

    John Choi, Nicholas Mai, Christopher Jackson, Zineb Belcaid, Michael Lim

    Microglia and macrophages, two myeloid cell lineages with different origins, make up the majority of immune cells present in glioblastoma (GBM). However, much of the literature does not distinguish between microglia and macrophages, despite a growing body of evidence that demonstrates key... Read more

    This article belongs to the Special Issue Immunotherapeutic Approaches for Treatment of Brain Tumors Neuroimmunol Neuroinflammation 2018;5:42. | doi:10.20517/2347-8659.2018.47
    Published on: 18 Oct 2018  | Viewed:34  | Downloaded:2
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    Original Article| Open Access

    Changes in microglia activity of rat brain induced by Macrovipera lebetina obtusa venom

    Anna A. Darbinyan, Marina V. Antonyan, Hasmik R. Koshatashyan, Susanna S. Gevorgyan, Hovhannes V. Arestakesyan, Zaruhi I. Karabekian, Naira M. Ayvazyan, Armen V. Voskanyan

    Aims: The microglia activity of rat brain following exposure of the Macrovipera lebetina obtusa venom was investigated. Methods: Histochemical analysis of brain microcirculatory bed staining by Ca2+ ATPase method for variable doses after intraperitoneal injections given for different time... Read more

    Neuroimmunol Neuroinflammation 2018;5:41. | doi:10.20517/2347-8659.2018.33
    Published on: 29 Sep 2018  | Viewed:279  | Downloaded:9
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    Review| Open Access

    Presynaptic mechanisms at prefrontal synapses involved in persistent pain

    Hiroki Toyoda

    The cumulative evidence from animal and human studies revealed that the anterior cingulate cortex (ACC) plays essential roles in pain sensation and persistent pain. It has been evident in the ACC synapses of animals that changes in both the presynaptic and postsynaptic function are caused by... Read more

    Neuroimmunol Neuroinflammation 2018;5:40. | doi:10.20517/2347-8659.2018.48
    Published on: 29 Sep 2018  | Viewed:138  | Downloaded:5
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    Letter to Editor| Open Access

    Azygos anterior cerebral artery aneurysm with subarachnoid hemorrhage

    Dhiman Chowdhury, Nazmin Ahmed, Bipin Chaurasia, Kanak Kanti Barua Neuroimmunol Neuroinflammation 2018;5:39. | doi:10.20517/2347-8659.2018.37
    Published on: 28 Sep 2018  | Viewed:238  | Downloaded:28
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    Original Article| Open Access

    Predictors of severity and outcome and roles of intravenous thrombolysis and biomarkers in first ischemic stroke

    Kartick Chandra Ghosh, Ramesh Bhattacharya, Saikat Ghosh, Manoj Mahata, Sarbajit Das, Suman Das, Gourango Prosad Mondal

    Aim: Stroke is one of the leading causes of death and disability. The proportion of patients receiving recombinant tissue plasminogen activator is low in our country. Biomarkers to identify patients at risk of severe disease, and guide treatment and prognosis would be valuable. This article aims... Read more

    Neuroimmunol Neuroinflammation 2018;5:38. | doi:10.20517/2347-8659.2018.28
    Published on: 27 Sep 2018  | Viewed:214  | Downloaded:15
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    Meeting Abstracts| Open Access

    2018 Mental Health and Neurology Conference

    Moh Hasan Machfoed Neuroimmunol Neuroinflammation 2018;5:37. | doi:10.20517/2347-8659.2018.45
    Published on: 25 Sep 2018  | Viewed:184  | Downloaded:8
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    Review| Open Access

    Glioma associated microglia/macrophages, a potential pharmacological target to promote antitumor inflammatory immune response in the treatment of glioblastoma

    Cinzia Dello Russo, Natalia Cappoli

    Glioma associated microglia/macrophages (GAMs) constitute the largest proportion of glioma infiltrating cells, particularly in high grade tumors (i.e., glioblastoma). Once inside the tumors, GAMs usually acquire a specific phenotype of activation that favors tumor growth, angiogenesis and... Read more

    This article belongs to the Special Issue Immunotherapeutic Approaches for Treatment of Brain Tumors Neuroimmunol Neuroinflammation 2018;5:36. | doi:10.20517/2347-8659.2018.42
    Published on: 20 Sep 2018  | Viewed:433  | Downloaded:45
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    Erratum| Open Access

    Erratum: Characteristics and predictive biomarkers of drug resistant epilepsy -- study in Georgia

    Neuroimmunology and Neuroinflammation Editorial Office Neuroimmunol Neuroinflammation 2018;5:35. | doi:10.20517/2347-8659.2018.54
    Published on: 6 Sep 2018  | Viewed:200  | Downloaded:12
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    Original Article| Open Access

    The novel-molecule T11TS facilitated arousal of glioma-mediated dormancy of bone-marrow hematopoietic stem-cells

    Somnath Mondal, Ankur Datta, Iman Hazra, Sk Md Omar Faruk, Saibal Moitra, Suhnrita Chaudhuri, Lakshyajeet Nath, Prasanta Kumar Das, Anjan Kumar Basu, Santanu Kumar Tripathi, Swapna Chaudhuri

    Aim: T11TS, a potent anti-gliomagenic glycoprotein, stimulates both peripheral and intracranial immune response. The status of bone marrow hematopoietic stem cells (BMHSCs), the cradle of regeneration of all blood cells, during gliomagenic global immune devastations has not yet been investigated.... Read more

    This article belongs to the Special Issue Immunotherapeutic Approaches for Treatment of Brain Tumors Neuroimmunol Neuroinflammation 2018;5:34. | doi:10.20517/2347-8659.2018.13
    Published on: 30 Aug 2018  | Viewed:522  | Downloaded:18
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