fig1

Figure 1. Experimental protocol for treatment of mice with chlorpyrifos oxon. This figure illustrates the protocol for the treatment of transgenic Alzheimer's disease mouse model utilized in this study. (a) Treatment of pregnant female amyloid precursor protein (APP) mice for 3-week during gestation; (b) treatment of female APP mice after birth and for 3-week during lactation; (c) treatment of APP mice following weaning until termination of the study at 6 months. All animals were assessed behaviorally prior to sacrifice. -3w, indicates time of plug following when male and female APP mice were placed together; 0, indicates time at birth; +3w, indicates time of weaning of APP mice