fig2

Figure 2. Treatment of amyloid precursor protein (APP) mice with chlorpyrifos oxon (CPO) results in diminished memory acquisition. APP mice (control, cornoil alone) and APP mice treated with CPO (CPO) from the different groups at 6 months of age were trained in the Morris water maze test on each of 4 consecutive days to learn the location of a submerged, invisible platform in a pool of water. The time that it took the mice to swim to the platform was recorded each day, measured as the latency period (in seconds, s), with shorter latency times indicating better memory acquisition. Latency (s) is shown as mean ± standard error of the mean (statistical significance, *P < 0.05, **P < 0.01, compared to APP control group; n = 12 per group)