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Figure 4. Schematic representation of modulators of oligodendrogenesis in the adult brain. Wnt and Notch positively regulate neural stem cells self‑renewal. Fibroblast growth factor‑2, laminin, Ascl1, Nkx6.1/6.2, Sox 8/9, miRNA‑7a and histone methylation positively modulate oligodendrocyte fate. Histone acetylation inhibits while epidermal growth factor and platelet‑derived growth factor receptor α promotes oligodendrocyte precursor cell differentiation. Sirt1 and bone morphogenic proteins block while Insulin‑like growth factor‑1 stimulates oligodendrocyte differentiation