fig3

Figure 3. Histologic analysis of the biopsy sample. (a) Histologic sections show a background of reactive fibrosis (arrow) with nodular inflammatory cell infiltrates (between vertical lines). Higher magnification (×10); (b) chronic inflammatory cells: small mononuclear cells (arrow head) and nodular aggregates of pale pink "epithelioid" histiocytes (arrow) imparting a granulomatous appearance (×20); (c) Small spherical organisms are seen (arrow head) and focally a few neutrophils are present in the center of the granuloma (arrow, ×40); (d) GMS staining confirms the presence of fungal organisms that morphologically appear as small dark stained round yeast forms (arrow). Blastomyces dermatitidis (×40).