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Figure 2. (a) Histological examination revealed a neoplasm with highly pleomorphic cells exhibiting several mitoses (arrows); (b) microvascular proliferation was also evident, a common finding in high grade gliomas (arrows); (c) some areas of the biopsied tumor showed evidence of radiation-induced changes, such as necrosis (arrows) and vascular changes such as telangiectasia and hyalinization of vessel walls adjacent to areas of hypercellular tumor tissue (arrows); (d) the proliferation marker MIB1 (Ki67) was expressed in a high proportion of tumor cells (arrows)