Topic: Stroke

Download All Articles

A special issue of Neuroimmunology and Neuroinflammation  (Print ISSN:2347-8659; Online ISSN:2349-6142).

Deadline for manuscript submissions: 29 Apr 2017

Share This Special Issue

Guest Editor(s)

  • Prof. Hua Su, MD
    Center for Cerebrovascular Research, Department of Anesthesia, University of California, San Francisco, CA, USA.

    Website | E-mail

Special Issue Introduction:

This special issue assembled a collection of articles from renowned experts in the field of brain injury and neuroinflammation, and attempted to lift some of the veil on the pathophysiology of stroke. A review and a mini review in this issue reviewed the role of inflammation in brain injury, the sources of inflammation and the potential therapeutic targets. The impact of genetic variations on stroke occurrence, brain injuries and recovery was also discussed using endoglin gene, a transforming growth factor beta associated receptor, as an example. In addition, a clinical study presented in this issue demonstrated a correlation of cerebral microbleed and the level of inflammatory markers in blood.

Keywords:

Stroke, brain injury, neuroinflammation, endoglin, microbleed, inflammatory markers

Submission Information:

For Author Instructions, please refer to http://nnjournal.net/pages/view/author_instructions
For Online Submission, please login at http://www.editorialmanager.com/neurimm/default.aspx
Submission Deadline: 29 Apr 2017
Contacts: Ruirui Zhang, Managing Editor, editor001@nnjournal.net

Published Articles Download All Articles
  • Inflammation and genetic factors in stroke pathogenesis

    Hua Su
    Neuroimmunol Neuroinflammation 2017;4:260-2. | doi:10.20517/2347-8659.2017.22
    Published on: 8 Dec 2017  | Viewed:1043  | Downloaded:83
    +HTML| PDF
  • The roles of endoglin gene in cerebrovascular diseases

    Wan Zhu , Li Ma , Rui Zhang , Hua Su
    Endoglin (ENG, also known as CD105) is a transforming growth factor β (TGFβ) associated receptor and is required for both vasculogenesis and angiogenesis. Angiogenesis is important in the development of cerebral vasculature and in the pathogenesis of cerebral vascular diseases. ENG is an essential component of the endothelial nitric oxide synthase activation complex. Animal studies showed that ENG deficiency impairs stroke recovery. ENG deficiency also impairs the regulation of vascular tone, which contributes to the pathogenesis of brain arteriovenous malformation (bAVM) and vasospasm. In... Read more
    Neuroimmunol Neuroinflammation 2017;4:199-210. | doi:10.20517/2347-8659.2017.18
    Published on: 17 Oct 2017  | Viewed:2225  | Downloaded:91
    +HTML| PDF
  • Role of neuroinflammation in ischemic stroke

    Rui Liu , Meng-Xian Pan , Jun-Chun Tang , Ya Zhang , Hua-Bao Liao , Yang Zhuang , Dan Zhao , Qi Wan
    Ischemic stroke causes the depletion of energy and induce excitotoxicity and neuroinflammation in the brain that results from thrombotic blockage. Neuroinflammation occurs initially depending on activated resident microglia that has the same function as the macrophage. Activated microglia participates in the neuroinflammatory process by phagocytosing the injured brain cells and producing the pro- and anti-inflammatory mediators. In this review, the authors present an overview of the role of microglia in mediating neuroinflammation in ischemic stroke. Read more
    Neuroimmunol Neuroinflammation 2017;4:158-66. | doi:10.20517/2347-8659.2017.09
    Published on: 28 Aug 2017  | Viewed:7858  | Downloaded:357
    +HTML| PDF
  • Relationship of cerebral microbleeds to inflammatory marker levels

    Qiao-Li Lu , Chen Li , Ying Song , Liang Wang , Zhi-Rong Jia
    Aim: The purpose of this study is to investigate the incidence, distribution and risk factors of cerebral microbleeds (CMBs) and the relation between CMBs and inflammation in ischemic cerebrovascular disease. Methods: Two hundred and one patients without acute infarction or transient ischemic attack were enrolled. The presence and number of CMB were assessed on susceptibility-weighted imaging. The traditional risk factors of CMB were recorded. Levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and matrix metalloproteinase-9 (MMP-9) were tested. Logistic regression... Read more
    Neuroimmunol Neuroinflammation 2017;4:145-51. | doi:10.20517/2347-8659.2017.05
    Published on: 8 Aug 2017  | Viewed:2055  | Downloaded:110
    +HTML| PDF
  • When friend turns foe: central and peripheral neuroinflammation in central nervous system injury

    Paul Marcet , Nicole Santos , Cesar V. Borlongan
    Injury to the central nervous system (CNS) is common, and though it has been well studied, many aspects of traumatic brain injury (TBI) and stroke are poorly understood. TBI and stroke are two pathologic events that can cause severe, immediate impact to the neurostructure and function of the CNS, which has been recognized recently to be exacerbated by the body’s own immune response. Although the brain damage induced by the initial trauma is most likely unsalvageable, the secondary immunologic deterioration of neural tissue gives ample opportunity for therapeutic strategists seeking to... Read more
    Neuroimmunol Neuroinflammation 2017;4:82-92. | doi:10.20517/2347-8659.2017.07
    Published on: 17 May 2017  | Viewed:4284  | Downloaded:245
    +HTML| PDF
  • Cerebral ischemia at early postoperative period of direct revascularization for moyamoya disease: a case report and literature review

    Xiao-Lin Chen , Li Ma , Yu Chen , Jun-Lin Lu , Xun Ye , Rong Wang , Yuan-Li Zhao
    Hypoperfusion and hyperperfusion could be causes of early postoperative complications that lead to neurological deterioration in patients with moyamoya diseases (MMD) after superficial temporal artery (STA) and middle cerebral artery (MCA) anastomosis. Here, the authors described a case of child-onset bilateral MMD that manifested transient cerebral ischemia in the contralateral hemisphere after left STA-MCA bypass in young adulthood. A new onset of cerebral ischemia in the contralateral hemisphere and transient neurological deterioration suggested the fragile hemodynamics of MMD during... Read more
    Neuroimmunol Neuroinflammation 2017;4:46-53. | doi:10.20517/2347-8659.2017.04
    Published on: 24 Mar 2017  | Viewed:2427  | Downloaded:154
    +HTML| PDF
Neuroimmunology and Neuroinflammation ISSN 2349-6142 (Online), ISSN 2347-8659 (Print)
Partners
Copyright © 2018 OAE Publishing Inc. All Rights Reserved.