Topic: The Role of Inflammation in Cerebral Aneurysms

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A special issue of Neuroimmunology and Neuroinflammation  (Print ISSN:2347-8659; Online ISSN:2349-6142).

Deadline for manuscript submissions: 1 Feb 2015

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Guest Editor(s)

  • Dr. Dale Ding, MD
    Barrow Neurological Institute, Department of Neurosurgery Phoenix, AZ, USA.

    Website | E-mail

Special Issue Introduction:

The pathophysiology of cerebral aneurysms is complex and multifactorial. Inflammation has been shown to be an important contributor to the pathogenesis of cerebral aneurysms. Herein, we have assembled a collection of articles from renowned experts in the field of cerebrovascular disease, in order to clarify the current understanding of the role of inflammation in the formation, progression, and ruptured of cerebral aneurysms, as well as to delineate future directions for continued investigations.


Immune system, inflammation, intracranial aneurysm, intracranial hemorrhages, leukocyte, stroke, subarachnoid hemorrhage

Submission Information:

For Author Instructions, please refer to
For Online Submission, please login at
Submission Deadline: 1 Feb 2015
Contacts: Ruirui Zhang, Managing Editor,

Published Articles Download All Articles
  • Inflammation of the cerebral arteries: lifting the veil on the pathobiology of intracranial aneurysms

    Dale Ding
    Neuroimmunol Neuroinflammation 2015;2:49-50. | doi:10.4103/2347-8659.153968
    Published on: 15 Apr 2015  | Viewed:3568  | Downloaded:167
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  • Advances in the imaging of cerebral aneurysm inflammation

    Michael R. Levitt , M. Yashar S. Kalani , Karam Moon , Cameron G. McDougall , Felipe C. Albuquerque
    Cerebral aneurysm formation, growth and rupture are thought to be the result of a complex interaction between cerebrovascular hemodynamics and pathobiology. Recently, new evidence has emerged regarding the role of inflammation in the walls of cerebral aneurysms. Noninvasive methods to characterize the degree of inflammation in aneurysms could enable clinicians to estimate the risk of future... Read more
    Neuroimmunol Neuroinflammation 2015;2:51-4. | doi:10.4103/2347-8659.153970
    Published on: 15 Apr 2015  | Viewed:4863  | Downloaded:190
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  • Cerebral aneurysms and inflammation

    Toshihiro Yokoi , Makoto Saito , Yayoi Yoshimura , Keiichi Tsuji , Kazuhiko Nozaki
    Multiple inflammatory factors, playing a crucial role in cerebral aneurysm formation, have been identified. Tumor necrosis factor-alpha (TNF-α) has been revealed to have a close connection with several risk factors that affect aneurysm formation. Remarkable expression in aneurysm walls of mRNA for TNF-α has been observed in humans. Possible therapeutic interventions to reduce the formation of... Read more
    Neuroimmunol Neuroinflammation 2015;2:55-8. | doi:10.4103/2347-8659.153977
    Published on: 15 Apr 2015  | Viewed:5082  | Downloaded:143
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  • Hemodynamics, inflammation, vascular remodeling, and the development and rupture of intracranial aneurysms: a review

    Francesco Signorelli , Benjamin Gory , Roberto Riva , Paul-Emile Labeyrie , Isabelle Pelissou-Guyotat , Francis Turjman
    The central nervous system is an immunologically active environment where several components of the immune and inflammatory response interact among them and with the constituents of nervous tissue and vasculature in a critically orchestrated manner, influencing physiologic and pathologic processes. In particular, inflammation takes a central role in the pathogenesis of intracranial aneurysms... Read more
    Neuroimmunol Neuroinflammation 2015;2:59-67. | doi:10.4103/2347-8659.154885
    Published on: 15 Apr 2015  | Viewed:5796  | Downloaded:201
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  • Inflammation and intracranial aneurysms: mechanisms of initiation, growth, and rupture

    Peter S. Amenta , Edison Valle , Aaron S. Dumont , Ricky Medel
    Outcomes following aneurysmal subarachnoid hemorrhage remain poor in many patients, despite advances in microsurgical and endovascular management. Consequently, considerable effort has been placed in determining the mechanisms of aneurysm formation, growth, and rupture. Various environmental and genetic factors are implicated as key components in the aneurysm pathogenesis. Currently, sufficient... Read more
    Neuroimmunol Neuroinflammation 2015;2:68-76. | doi:10.4103/2347-8659.153975
    Published on: 15 Apr 2015  | Viewed:4929  | Downloaded:205
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  • Inflammation in human cerebral aneurysms: pathogenesis, diagnostic imaging, genetics, and therapeutics

    Sarah A. Dooley , Joseph S. Hudson , David M. Hasan
    Intracranial aneurysms are a life-threatening cerebrovascular pathology with a probability of spontaneous rupture. Current intervention techniques carry inherent risk. Recent investigation has reinforced inflammation’s role in the pathophysiological process of cerebral aneurysms. These data suggest alternative diagnostic and noninvasive therapeutic strategies. Furthermore, novel characteristics... Read more
    Neuroimmunol Neuroinflammation 2015;2:77-85. | doi:10.4103/2347-8659.154433
    Published on: 15 Apr 2015  | Viewed:6849  | Downloaded:181
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  • Inflammation mediates the pathogenesis of cerebral aneurysm and becomes therapeutic target

    Tomohiro Aoki
    The treatment of cerebral aneurysms (CAs) is of social importance, because poor outcomes result in subarachnoid hemorrhages after rupture. However, there is currently no medical treatment available to prevent the progression and rupture of CAs, which results in a large number of patients without receiving treatment. Recent studies using human samples have revealed the presence of inflammatory... Read more
    Neuroimmunol Neuroinflammation 2015;2:86-92. | doi:10.4103/2347-8659.154381
    Published on: 15 Apr 2015  | Viewed:7193  | Downloaded:168
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  • Role of the complement cascade in cerebral aneurysm formation, growth, and rupture

    Blake E. S. Taylor , Geoff Appelboom , Robert Zilinyi , Ariana Goodman , David Chapel , Melissa LoPresti , Edward Sander Connolly Jr.
    Rupture of intracranial aneurysms is the most common cause of nontraumatic subarachnoid hemorrhage, but the intricate neuroinflammatory processes which contribute to aneurysm pathophysiology are not well-understood. Mounting evidence has implicated the complement cascade in the progression of aneurysms from their formation to rupture. In this article, we identify and review studies that have... Read more
    Neuroimmunol Neuroinflammation 2015;2:93-101. | doi:10.4103/2347-8659.154888
    Published on: 15 Apr 2015  | Viewed:30208  | Downloaded:290
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  • The role of inflammation in cerebral aneurysms

    Ali H. Turkmani , Nancy J. Edwards , Peng R. Chen
    The natural history of unruptured intracranial aneurysms (IAs) is poorly understood. At present, risk factors for aneurysm rupture are limited to demographics and rudimentary anatomic features of the aneurysm. The first sign of aneurysm destabilization and rupture may be subarachnoid hemorrhage, a potentially devastating brain injury with high morbidity and mortality. An emerging body of... Read more
    Neuroimmunol Neuroinflammation 2015;2:102-6. | doi:10.4103/2347-8659.153982
    Published on: 15 Apr 2015  | Viewed:6293  | Downloaded:251
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  • The role of leukocytes in the formation and rupture of intracranial aneurysms

    Michael J. Strong , Peter S. Amenta , Aaron S. Dumont , Ricky Medel
    Ruptured intracranial aneurysms (IAs) affect a small proportion of the population; however, the morbidity and mortality is disproportionally high. Although little is known about IA formation, progression, and rupture, mounting evidence suggests that inflammation may play an important role in IA pathogenesis. There is emerging evidence to suggest that leukocytes play a key role in generating and... Read more
    Neuroimmunol Neuroinflammation 2015;2:107-14. | doi:10.4103/2347-8659.153972
    Published on: 15 Apr 2015  | Viewed:4397  | Downloaded:147
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Neuroimmunology and Neuroinflammation ISSN 2349-6142 (Online), ISSN 2347-8659 (Print)
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