- Dr. Christiane Charriaut-Marlangue
- NeuroDiderot - INSERM U1141. Université Paris Diderot, Sorbonne Paris Cité, Hôpital Robert Debré, 48 boulevard Sérurier, 75019 Paris, France
Special Issue Introduction
Stroke is a disorder affecting all age groups, particularly those at opposite ends of the age spectrum, with an incidence of 1/2800 to 1/5000 life infant births, and more than 6 million cases every year in adult stroke, respectively. To date, there is still no effective treatment that increases the survival rate or improves the quality of life both during the neonatal period (the first 28 days of life) and/or in adulthood. During the last decade, the male sex appeared to be a determinant factor, not only in the worse outcome (during the first 40-50 years of life) but also in response to cellular and molecular pathways activated in different cerebral area involved in behavioral functions.
Stroke triggers dysfunction in several pathways, with multiple final outcomes which include multiple paths to death or to recovery. The activation of resident microglial cells, alongside the infiltration of peripheral macrophages, represents a central inflammatory response to ischemic stroke leading to secondary injury cascade associated with neuronal death. Microglia/macrophages are the main players in propagating inflammation to tissues neighboring the core site of injury. They perform this task through the production of inflammatory mediators including cytokines and chemokines.
For this special issue of the journal, we request submission of manuscripts concerning the molecular pathways in microglia/macrophage and immune (infiltration of peripheral myeloid cells including polymorphonuclear, lymphocytes and monocytes) responses after stroke in pre-clinical studies.
Submissions especially (but not exclusively) on the following topics are welcomed:
- specific microglial gene and region differences between male and female brains
- specific microglial responses according to the developmental stage of ischemic animals
- specific microglial responses according to rodent species used in the stroke models.
These data may highlight the development of add-on sex-specific therapeutically strategies in stroke units.
KeywordsLesion, ischemic core, ischemic peri-infarct, macrophage, microglia, neuroinflammation, sex-differences, polymorphonuclear, lymphocytes, monocytes.
Submission Deadline30 Apr 2020